Hyperoside;Hypercin Cas No. 482-36-0
Ulwazi lweziyobisi
[igama lemveliso] hypericin
[Igama lesiNgesi] Hyperoside
[igama elingelilo] hyperin, quercetin 3-galactoside, quercetin-3-o-galactoside
[ifomula yemolekyuli] c21h20o12
[ubunzima bemolekyuli] 464.3763
[C njengeNombolo] 482-36-0
[ukuhlelwa kweekhemikhali] i-flavonoids
[umthombo] Hypericum perforatum L
[Inkcazo] > 98%
[Isigama sokhuseleko] 1. Musa ukuphefumla uthuli.2. Kwimeko yengozi okanye ukungakhululeki, funa unyango ngokukhawuleza (bonisa ileyibhile yayo ukuba kunokwenzeka).
[Ukusebenza kwe-Pharmacological] I-Hypericin isasazwa ngokubanzi.Yimveliso ebalulekileyo yendalo kunye nemisebenzi eyahlukeneyo ye-physiological, efana ne-anti-inflammatory, antispasmodic, diuretic, ukukhwehlela, ukunciphisa uxinzelelo lwegazi, ukunciphisa i-cholesterol, i-protein assimilation, i-analgesia yendawo kunye ne-central, kunye nemiphumo yokukhusela kwintliziyo kunye nemithambo ye-cerebral.
[Iimpawu ezibonakalayo kunye neekhemikhali] Ikristale etyheli eneacicular.Indawo yokunyibilika yi-227 ~ 229 ℃, kwaye ukujikeleza kwe-optical yi-83 ° (C = 0.2, pyridine).I-soluble ngokulula kwi-ethanol, i-methanol, i-acetone kunye ne-pyridine kwaye izinzile phantsi kweemeko eziqhelekileyo.Isabela nge-hydrochloric acid magnesium powder ukuvelisa i-cherry ebomvu, kunye ne-ferric chloride isabela eluhlaza, i-α- Naphthol reaction yayilungile.
[Isigama somngcipheko] Inobungozi xa iginyiwe.
Isenzo se-Pharmacological
1. I-Hypericin inempembelelo ebalulekileyo ye-analgesic yendawo, ebuthakathaka kune-morphine, enamandla kune-aspirin, kwaye ayinakho ukuxhomekeka.I-Hypericin luhlobo olutsha lwe-analgesic yendawo Ngexesha elifanayo,
2. I-Hypericin inefuthe elihle lokukhusela kwi-myocardial ischemia-reperfusion, i-cerebral ischemia-reperfusion kunye ne-cerebral infarction.
3. I-Hypericin inomphumela ocacileyo wokuchasana nokuvuvukala: emva kokufakelwa kwebhola yoboya, iigundane zafakwa intraperitoneally nge-20mg / kg yonke imihla ngeentsuku ze-7, ezithintela kakhulu inkqubo yokuvuvukala.
4. Inempembelelo enamandla ye-antitussive.
5. Ukulinganisa.
6. Ukuthintela okuqinileyo kwe-aldose reductase kunokuba luncedo ekuthinteleni i-cataract yesifo seswekile.
Impembelelo yokukhusela kwi-ischemia ye-myocardial
I-Hypericin inokunciphisa izinga le-apoptosis ye-cardiomyocytes ebangelwa i-hypoxia reoxygenation, inqanda ukukhululwa kwe-lactate dehydrogenase, ukuphucula umsebenzi we-myocardial superoxide dismutase (SOD) kwiigundane ezinokulimala kwe-myocardial ischemia-reperfusion, ukunciphisa ukuveliswa kwe-malondialdehyde (MDA), inhibit ukwanda kwe-myocardial phosphokinase (CPK) kwi-serum, kunye nokunciphisa ukubunjwa kwe-oxygen free radical and nitric oxide free radical, Ukuze ukhusele i-myocardium kunye nokunciphisa ukulimala kwe-cardiomyocyte kunye ne-cardiomyocyte apoptosis ebangelwa yi-ischemia-reperfusion.
Impembelelo yokukhusela kwi-cerebral ischemia
I-Hypericin inokuthintela ngokufanelekileyo ukuhla komxholo we-formazan kwi-cerebral slices emva kokulimala kwe-hypoxia glucose deprivation reperfusion, ukwandisa inani le-neurons ephilayo kwi-cortex kunye ne-striatum ye-cerebral slices kwindawo ye-ischemic, kwaye wenze i-morphology ye-neurons iphelele kwaye isasazwe kakuhle.Ukuthintela ukuncipha komsebenzi we-neuronal obangelwa yi-hypoxia glucose deprivation reperfusion ukulimala.Ukuthintela ukuncipha kwemisebenzi ye-SOD, LDH kunye ne-glutathione peroxidase (GSHPx).Indlela yayo inokuthi ihambelane ne-free radical scavenging, inhibition of Ca2 influx kunye ne-anti lipid peroxide formation.
Impembelelo yokukhusela kwisibindi kunye ne-gastric mucosa
I-Hypericin inefuthe elicacileyo lokukhusela kwizicubu zesibindi kunye ne-gastric mucosa.Indlela yayo inxulumene nesiphumo se-antioxidant, ukukhuthaza ukubuyiswa kwenqanaba le-N0 ukuya kwisiqhelo kunye nokwandisa umsebenzi we-SOD.
Impembelelo ye-Antispasmodic analgesic
Uphononongo lufumene ukuba umphumo we-analgesic we-hypericin uveliswa ngokunciphisa i-Ca 2 kwiiphelo ze-nerve ezibuhlungu.Ngelo xesha, i-hypericin inokuthintela ukungena kwe-Ca 2 okubangelwa yi-potassium ephezulu, ebonisa ukuba i-hypericin iphinda ivimbele i-Ca channel kwi-nerve tissue.Kwakhona kucetywayo ukuba i-hypericin inokuba yi-blocker ye-Ca 2 channel.Ukuqwalaselwa kweklinikhi kubonisa ukuba inaliti ye-hypericin ifana ne-atropine kunyango lwe-primary dysmenorrhea.Ngaphandle kweziphumo ebezingalindelekanga ezimbalwa zobuthongo, ayinazo iziphumo ezibi eziqhelekileyo ezifana ne-tachycardia, i-mydriasis kunye nokuvutha komsindo.Yinto efanelekileyo ye-antispasmodic kunye ne-analgesic.
Impembelelo ye-Hypolipidemic
I-Hypericin inokunciphisa kakhulu i-serum TC kunye nokwandisa umlinganiselo we-HDL / TC kwiigundane ezinamafutha aphezulu, ebonisa ukuba i-hypericin inokunciphisa i-cholesterol, ilawula i-lipid yegazi, kwaye iphucule umsebenzi we-HDL kunye ne-SOD ye-serum kwiigundane.Esi siphumo sinokunciphisa kakhulu umonakalo we-superoxide yamahhala kwi-vascular endothelium kwi-hyperlipidemia, kwaye ilungele ukubola kunye ne-metabolism ye-lipid peroxide ukukhusela i-vascular endothelium.
Ukuphucula ukusebenza komzimba
I-Hypericin kwiidosi ze-300 mg / kg kunye ne-150 mg / kg kwi-vivo inokuthintela ngokuphawulekayo isalathisi se-thymus, ukwanda kwe-spleen T kunye ne-B lymphocytes kunye ne-phagocytosis ye-macrophages ye-peritoneal;Kwi-59 mg / kg, ikhulise kakhulu ukwanda kwe-spleen T kunye ne-B lymphocytes kunye ne-phagocytosis ye-macrophages ye-peritoneal.I-Hypericin kwi-dose ye-50 ~ 6.25 ml kwi-vitro inokukhuthaza kakhulu ukwanda kwe-spleen T kunye ne-B lymphocytes kunye nokuphucula amandla e-T lymphocytes ukuvelisa i-IL-2;I-Hypericin kwi-6.25 g / ml inyuse kakhulu ikhono le-macrophages ye-mouse ye-peritoneal kwi-phagocytize neutrophils, ukusuka kwi-12.5 ukuya kwi-3.12 μ G / ml inyuse kakhulu ikhono le-macrophages ye-mouse peritoneal ukukhulula i-No.
Isiphumo sokuthomalalisa uxinzelelo
Ukusebenza kwe-Hypothalamic pituitary adrenal (HPA) lutshintsho oluqhelekileyo lwebhayoloji kwizigulane ezinoxinzelelo olunzima, olubonakaliswa ngokugqithiswa kwehomoni ye-adrenocorticotropic (ACTH) kunye ne-cortisol.I-Hypericin inokulawula umsebenzi we-axis ye-HPA kunye nokunciphisa amanqanaba e-ACTH kunye ne-corticosterone, ukwenzela ukuba idlale indima ye-antidepressant.
Iziyobisi ezigqityiweyo
Ciwujia capsule
I-Acanthopanax senticosus capsule lulungiselelo olune-Acanthopanax senticosus stem kunye ne-extract yegqabi njengento eluhlaza.Icandelo eliphambili li-flavonoids, apho i-hypericin iyona nxalenye esebenzayo yamagqabi e-Acanthopanax senticosus.
Iimpawu eziphambili: ukukhuthaza ukujikeleza kwegazi kunye nokususa i-stasis yegazi.Isetyenziselwa isifuba se-arthralgia kunye nesifo senhliziyo esibangelwa yi-stasis yegazi.Iimpawu ziquka intlungu yesifuba, ukuqina kwesifuba, ukubetha kwentliziyo, uxinzelelo lwegazi, njl.
Xinan capsule
Kuyilungiselelo elenziwe ngesicatshulwa seqabunga le-hawthorn, elinezityebi kwi-flavonoids, apho i-hypericin ingenye yezinto eziphambili.
Iimpawu eziphambili: ukwandisa inkqubo ye-coronary cardiovascular system, ukuphucula ukunikezelwa kwegazi le-myocardial kunye nokunciphisa i-lipid yegazi.Isetyenziselwa ukunyanga isifo senhliziyo, i-angina pectoris, ukuqina kwesifuba, ukubetha kwentliziyo, uxinzelelo lwegazi, njl.
Qiyue Jiangzhi tablet
Icwecwe le-Qiyue Jiangzhi lichiza elisulungekileyo lemveli laseTshayina le-lipid-ukwehlisa ichiza elilungiselelwe ngokukhupha iindawo ezisebenzayo zamayeza esintu amaTshayina afana ne-hawthorn (enucleated) kunye ne-Astragalus membranaceus.Enye yezinto eziphambili ezisebenzayo ze-hawthorn yi-flavonoids, apho umxholo we-hypericin uphezulu.
Iimpawu eziphambili: ukunciphisa i-lipid yegazi kunye nokuthambisa imithwalo yegazi.Isetyenziselwa ukuqinisa ukujikeleza kwegazi kunye nokulwa ne-arrhythmia kunye ne-hyperlipidemia.
Xinxuening tablet
Ithebhulethi ye-Xinxuening lulungiselelo oluhlanganisiweyo olwenziwe ngamayeza emveli aseTshayina afana ne-hawthorn kunye ne-pueraria.IHawthorn iyeza elisemthethweni leqela lethu.Iqukethe i-ursolic acid, i-Vitexin rhamnoside, i-hypericin, i-citric acid, njl., apho i-hypericin iyona nxalenye ephambili.
Iimpawu eziphambili: ukukhuthaza ukujikeleza kwegazi kunye nokususa i-stasis yegazi, i-dredging collaterals kunye nokunciphisa intlungu.Isetyenziselwa i-arthralgia yesifuba kunye ne-vertigo ebangelwa yintliziyo yegazi kunye ne-brain collaterals, kunye nesifo senhliziyo, i-hypertension, i-angina pectoris kunye ne-hyperlipidemia.
Yukexin capsule
I-Yukexin capsule liyeza eliqhelekileyo lamaShayina lamalungiselelo aphuhliswe kummiselo wamandulo, owenziwe ngeHypericum perforatum, i-wild jujube kernel, i-Albizzia bark, iGladiolus kunye namanye amayeza emveli aseTshayina.Ngokukodwa iqulethe i-hypericin, i-quercetin, i-quercetin, i-chlorogenic acid, i-caffeic acid, i-yimaning, i-hypericin kunye nezinye izinto.
Iimpawu eziphambili: ukudakumba kwengqondo okubangelwa ukungazinzi kwesibindi qi kunye nesimo sengqondo esibi.
