Isoliquiritin Apioside
Ukusetyenziswa kwe-Isoliquiritin Apioside
I-Isoliquiritin apioside, icandelo elihlukanisiweyo kwi-glycorrhizae radio rhome, yanciphisa kakhulu i-PMA eyenza ukunyuka komsebenzi we-MMP9 kwaye ivimbele i-PMA eyenza i-MAPK kunye ne-NF- κ B isebenze.I-Isoliquitin apioside inqanda ukuhlasela kunye ne-angiogenesis yeeseli zomhlaza kunye neeseli ze-endothelial.
Igama le-Isoliquiritin Apioside
Igama lesiTshayina:Isoliquiritin Apioside
Igama lesiNgesi:(E) -3- [4- [(2S,3R,4S,5S,6R)-3- [(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl] oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-1-(2,4-dihydroxyphenyl)prop-2-en-1-one
I-Bioactivity ye-Isoliquiritin Apioside
Inkcazo:i-isoliquitin apioside, inxalenye eyodwa kwi-glycorrhizae radio rhome, yanciphisa kakhulu ukunyuka kwe-PMA eyenziwa ngumsebenzi we-MMP9 kwaye ivimbele i-PMA eyenza i-MAPK kunye ne-NF- κ B isebenze.I-Isoliquitin apioside inqanda ukuhlasela kunye ne-angiogenesis yeeseli zomhlaza kunye neeseli ze-endothelial.
EzinxulumeneyoCiindidi:icandelo lophando > > umhlaza
Indlela yomqondiso > > I-MAPK / indlela yesignali ye-ERK > > p38 MAPK
Indlela yomqondiso > > i-enzyme ye-metabolic / iprotease > > i-MMP
Ekujoliswe kuko:MMP9
NF-kB
p38 MAPK
Isifundo se-in vitro:I-isorlicin inokuthintela ngokufanelekileyo umsebenzi we-gelation we-MMP-9 we-PMA eyenziwe ngeeseli ze-HT1080.I-Isoglycyrrhizin apigenin inciphisa ukwanda kwemveliso ye-MMP-9 kwiiseli ze-HT1080 ezenziwe yi-PMA, inamandla e-anti metastasis kunye ne-anti angiogenesis kwiiseli ezinobungozi kunye neeseli ze-endothelial, kwaye ayinayo i-cytotoxicity [1].
Isalathiso:[1].UKim A1, et al.Isoliquiritin Apioside Suppresses in vitro Invasiveness and Angiogenesis of Cancer Cells and Endothelial Cells.Front Pharmacol.2018 Dec 10;9:1455.
Iimpawu zePhysicochemical ye-Isoliquiritin Apioside
Ubuninzi: 1.6 ± 0.1 g / cm3
Indawo yokubilisa: 901.0 ± 65.0 ° C kwi-760 mmHg
Ifomula yemolekyuli: c26h30o13
Ubunzima bemolekyuli: 550.509
Indawo edanyazayo: 301.9 ± 27.8 ° C
Ubunzima obuchanekileyo: 550.168640
PSA:215.83000
IlogP:1.96
Uxinzelelo lomphunga: 0.0 ± 0.3 mmHg ku-25 ° C
Isalathiso seRefractive: 1.709
Igama lesiNgesi le-Isoliquiritin Apioside
I-2-Propen-1-enye, 1- (2,4-dihydroxyphenyl) -3-[4-[[2-O-[(2S,3R,4R))-tetrahydro-3,4-dihydroxy-4-(hydroxymethyl )-2-furanyl]-β-D-glucopyranosyl]oxy]phenyl]-, (2E)-
3-[(1E)-3-(2,4-Dihydroxyphenyl)-3-oxo-1-propen-1-yl]phenyl 2-O-[(2S,3R,4R)-3,4-dihydroxy-4 -(hydroxymethyl)tetrahydro-2-furanyl]-β-D-glucopyranoside
Neolicuroside
