I-Methylophiopogonanone A;Opogonanone A
Ukusetyenziswa kweMethylophiopogonanone A
I-Methylophiopogonanone A yi-flavonoid ekhutshwe kwi-Ophiopogon japonicas, ene-antioxidant kunye ne-anti-inflammatory effects.
Igama likaMethylophiopogonanone A
Igama lesiNgesi:
(3R)-3-(1,3-benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydrochromen-4-enye
Igama lesiTshayina:
Ophiopogon methyl flavanone a |methyl Ophiopogon dihydrohomoisoflavone a |methyl Ophiopogon flavanone a
Umsebenzi webhayoloji weMethylophiopogonanone A
Inkcazo: i-methylophiopogonanone A yi-flavonoid ekhutshwe kwi-Ophiopogon japonicas, ene-flavonoid
i-antioxidant kunye ne-anti-inflammatory effects.
Iindidi ezinxulumeneyo: indlela yomqondiso > > i-apoptosis > > i-apoptosis
inkalo yophando > > ukudumba / ukunganyangeki
Uphononongo lwe-In Vitro: i-methyl aspartate a (mo-a; 10 μ Mo (L / L) yehle kakhulu i-apoptosis kunye nentetho yeCaspase-3, yanda umlinganiselo we-Bcl-2 / Bax kunye nokubuyiselwa akukho mveliso.
kwandisa kakhulu ukusebenza kwe-PI3K / Akt / eNOS indlela kwiiseli ze-H9c2 phantsi kwe-H / R, ngelixa isiphumo sokukhusela se-mo-a sacinywa phambi kwe-PI3K inhibitor wortmannin (100 nmol / L) [1].
KwiSifundo seVivo: impembelelo yokukhusela ye-methylaspartate a (mo-a; 10mg / kg / D, PO) kumsebenzi wentliziyo emva kokulimala kwe-myocardial I / R [1].
Iimbekiselo: [1] He F, et al.I-Methylophiopogonanone A icinezela ischemia/i-reperfusion-induced myocardial apoptosis kwiimpuku ngokuvula indlela yokubonisa i-PI3K/Akt/eNOS.Acta Pharmacol Sin.2016 Jun;37(6):763-71.
Iimpawu zePhysicochemical zeMethylophiopogonanone A
Ubuninzi: 1.4 ± 0.1 g / cm3
Indawo yokuBilisa: 580.1 ± 50.0 ° C kwi-760 mmHg
Ifomula yemolekyuli: c19h18o6
Ubunzima beMolekyuli: 342.343
Indawo edanyazayo: 212.9 ± 23.6 ° C
Ubunzima obuchanekileyo: 342.110352
PSA:85.22000
IlogP:5.16
Uxinzelelo lomphunga: 0.0 ± 1.7 mmHg ku-25 ° C
Refractive Index: 1.654
Igama lesiNgesi likaMethylophiopogonanone A
(1,3-Benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydro-4H-chromen-4-enye
4H-1-Benzopyran-4-enye, 3-(1,3-benzodioxol-5-ylmethyl)-2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-
N1002
Methylophiopogonanone A
Inkonzo Yongjian
Inkonzo eCwangcisiweyo yeZixhobo zeNgcaciso zeMichiza yezamayeza zesiNtu zamaTshayina
I-Jiangsu Yongjian Pharmaceutical Technology Co., Ltd. ibandakanyeka ikakhulu kuphando olusisiseko lwezinto ezisebenzayo zamayeza esintu amaTshayina ngaphezulu kweminyaka elishumi.Ukuza kuthi ga ngoku, inkampani yenze uphando olunzulu kwiintlobo ezingaphezu kwe-100 zamayeza esintu aqhelekileyo asetyenziswa eTshayina, kwaye yakhupha amawaka eekhemikhali.
Inkampani inabasebenzi abaphezulu be-R & D kunye novavanyo olugqibeleleyo kunye nezixhobo zokuhlalutya kushishino, kwaye ikhonze amakhulu amaziko ophando lwezenzululwazi.Inokukhawuleza kwaye ihlangabezane neemfuno zabathengi
Ukwahlulwa kokungcola kweziyobisi, ukuLungisa kunye neNkonzo yokuQinisekisa uLwakhiwo
Ukungcola kwiziyobisi kuhambelana ngokusondeleyo nomgangatho, ukhuseleko kunye nokuzinza kwamachiza.Ukulungiswa kunye nokuqinisekiswa kwesakhiwo sokungcola kwiziyobisi kunokusinceda siqonde iindlela zokungcola kunye nokubonelela ngesiseko sokuphucula inkqubo yokuvelisa.Ngoko ke, ukulungiswa kunye nokwahlula ukungcola kubaluleke kakhulu kuphando lweziyobisi kunye nophuhliso.
Nangona kunjalo, umxholo wokungcola kwiyeza liphantsi, umthombo ubanzi, kwaye isakhiwo sininzi sifana necandelo eliphambili.Yeyiphi itekhnoloji enokusetyenziswa ukwahlula kunye nokucoca bonke ukungcola kwichiza nganye nganye kwaye ngokukhawuleza?Zeziphi iindlela neendlela ezisetyenziswayo ukuqinisekisa ubume bobu kungcola?Obu bubunzima kunye nomngeni ojongene namacandelo amaninzi oxubo mayeza, ngakumbi amashishini axuba amayeza ezityalo kunye namayeza elungelo elilodwa lomenzi wechina.
Ngokusekwe kwiimfuno ezinjalo, inkampani iye yasungula ukwahlulwa kokungcola kweziyobisi kunye neenkonzo zokucoca.Ukuxhomekeka kwi-resonance yamagnetic yenyukliya, i-spectrometry yobunzima kunye nezinye izixhobo kunye nobuchwepheshe, inkampani inokuchonga ngokukhawuleza ukwakheka kweekhompawundi ezahluliweyo, ukuze ihlangabezane neemfuno zabathengi.
SPF Animal Experiment
Indawo yolwakhiwo yendawo yovavanyo lwezilwanyana yi-1500 square metres, kubandakanywa i-400 square metres yendawo yovavanyo yenqanaba le-SPF kunye ne-100 yeemitha zesikwere selebhu yenqanaba le-P2 yeseli.Ikhokelwe ngoosonzululwazi base China Pharmaceutical University, yenza iqela lobugcisa elingundoqo elinenani lababuyileyo.Ukubonelela ngeemodeli zezilwanyana ezikumgangatho ophezulu, uyilo lokulinga, iiprojekthi zizonke kunye nezinye iinkonzo zophando lwenzululwazi yebhayoloji, ukufundisa kunye nophuhliso lwemizimveliso.
Umda woShishino
1. Ukutyisa izilwanyana ezincinci
2. Imodeli yezifo zezilwanyana
3. Ukunikezelwa kweprojekthi yasekholejini
4. Uvavanyo lwe-Pharmacodynamic kwi-vivo
5. Uvavanyo lwe-Pharmacokinetic
6. Inkonzo yokulinga iseli yethumba
Amandla Ethu
1. Gxininisa kwimifuniselo yokwenyani
2. Qinisekisa ngokungqongqo inkqubo
3. Utyikitye ngokungqongqo isivumelwano semfihlo
4. Ilabhoratri yeyakho ngaphandle kwamakhonkco aphakathi
5. Iqela lobugcisa lobuchwephesha liqinisekisa umgangatho wokulinga
Imekobume yovavanyo ye-SPF, ukondla umntu owabelwe ngokukhethekileyo, ukulandelela ixesha lokwenyani inkqubela yovavanyo
