Ophiopogonin D Cas No.945619-74-9
Ophiopogon Saponin D Igama
Igama lesiNgesi:(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranoside
Ukusebenza kweBiopopogon Japonicus Saponin D
Inkcazo:I-Ophiopogon D yindalo enqabileyo i-C29 steroidal glycoside ebekwe yodwa kwi-tuber ye-Ophiopogon japonicus.I-Ophiopogonin D yi-CYP2J3 inducer eyandisa i-CYP2J2 / eets kunye ne-PPAR kwiiseli ze-umbilical vein endothelial cells (HUVECs) α Ukubonakaliswa kwe-Ang II kuthintele kakhulu i-Ang II eyenza i-NF- κ B i-nuclear translocation, I κ B α Down regulation, intracellular Ca2 ukulayisha ngokweqile kunye nokusebenza kwee-cytokines ze-proinflammatory.I-Ophiopogonin D isetyenziselwe ukunyanga ukuvuvukala kunye nezifo zentliziyo kangangamawaka eminyaka.
Iindidi ezifanelekileyo
Indlela yokubonakalisa imiqondiso > > uthutho lwe-transmembrane > > umjelo we-calcium
Indawo yophando > > isifo sentliziyo
Indlela yokubonisa > > umjikelo weseli / umonakalo weDNA > > PPAR
Inkalo yophando > > ukudumba / ukunganyangeki
Ekujoliswe kuko
PPARA
NF-kB
Ca2+
Amaxwebhu eReferensi:[1].Wang L, kunye nabanye.I-Homo-aro-cholestane, i-furostane kunye ne-spirostane saponins ukusuka kwii-tubers ze-Ophiopogonjaponicus.IPhytochemistry.2017 Epreli; 136: 125-132.
[2].Huang X, et al.I-Ophiopogonin D kunye ne-EETs ziphucula iimpendulo ezivuthayo ze-Ang II ngokusebenzisa i-PPARα kwi-HUVECs.I-Biochem Biophys Res Commun.2017 Aug 19; 490 (2): 123-133.
Igama lesiNgesi elithi Ophiopogon saponin D
(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranoside β-D-Galactopyranoside, (1β,3β,25R)-3-hydroxyspirost-5-en-1-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[β-D-xylopyranosyl-(1->3)]-6-deoxy-
(2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-5-hydroxy-2-((((4R,5'R,6R,6aR,6bS,8aS) ,8bR,9S,10R,11aS,12aS,12bS)-4-hydroxy-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a, 6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2 '-pyran] -6-yl) oxy) -6-methyl-4-(((2S,3R,4S,5R) -3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro- 2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol
Ophiopogonin D
I-Deacetylophiopogonin C
