Ammonium Glycyrrhizinate
Ohun elo ti Ammonium Glycyrrhizinate
Monoammonium glycyrrhizinate hydrate ni awọn iṣẹ elegbogi bii egboogi-iredodo, egboogi inira, ọgbẹ inu ati egboogi jedojedo.
Orukọ Ammonium Glycyrrhizinate
Orukọ Kannada:
Ammonium Glycyrrhizinate
Orukọ Gẹẹsi:
glycorrhizic acid iyọ amonia
KannadaAiro:
glycyrrhizic acid monoammonium hydrate |glycyrrhizic acid monoammonium hydrate |glycyrrhizic acid monoammonium iyọ |glycyrrhizic acid monoammonium iyọ |glycyrrhizic acid monoammonium iyọ hydrate |glycyrrhizic acid monoamonia
Bioactivity ti Ammonium Glycyrrhizinate
Apejuwe:monoammonium glycyrrhizinate hydrate ni awọn iṣẹ elegbogi bii egboogi-iredodo, egboogi inira, ọgbẹ inu ati egboogi jedojedo.
Awọn ẹka ti o jọmọ:
ọna ifihan agbara > > miiran > > miiran
Aaye iwadi > > igbona / ajesara
Ninu Ikẹkọ Vivo:ilosoke ti ẹdọfóró w / D iwuwo iwuwo dinku ni pataki nipasẹ iṣakoso ti iwọn giga ati alabọde ti magi (10 ati 30 mg / kg).Pretreatment pẹlu magi (10 ati 30 mg / kg) fe ni dinku TNF- α Ati IL-1 β Iran ti.Mag (10,30 mg / kg) dinku NF ni pataki ni akawe pẹlu LPS-κ Bp65 ikosile amuaradagba.Ni ifiwera, LPS dinku ni pataki ni akawe pẹlu ẹgbẹ iṣakoso κ B-a Protein ikosile, lakoko ti magn (10 ati 30 mg / kg) pọ si ni pataki I κ B- α Expression [1].Ti a bawe pẹlu awọn ẹgbẹ RIF ati INH, iwọn-kekere ati itọju MAG ti o ga ni pataki dinku ast, alt, TBIL ati awọn ipele TBA ni awọn ọjọ 14 ati 21, ti o nfihan ipa aabo ti MAG lori RIF - ati INH -.Jeki ipalara ẹdọ.Ẹgbẹ itọju MAG pọ si ipele GSH ẹdọ ni awọn ọjọ 7, 14 ati 21, ati pe o dinku ipele MDA ni pataki ni awọn ọjọ 14 ati 21 ni RIF ati awọn eku itọju INH, ti o nfihan ipa aabo ti MAG ni RIF - ati.INH fa ipalara ẹdọ fa [2].
Awọn idanwo ẹranko:eku [1] ninu iwadi yii, awọn eku BALB/c (ọkunrin, ọmọ ọsẹ 6-8, 20-25g) ni a lo.Awọn eku ti pin laileto si awọn ẹgbẹ 5: ẹgbẹ iṣakoso, ẹgbẹ LPS ati LPS + monoammonium glycyrrhizinate (Mag: 3,10 ati 30mg / kg).Ẹgbẹ kọọkan ni awọn eku 8 ninu.Awọn eku jẹ anesthetized pẹlu abẹrẹ intraperitoneal ti iṣuu soda pentobarbital (50 mg / kg).Awọn eku ni abẹrẹ intraperitoneally pẹlu magi (3, 10 ati 30 mg / kg) ṣaaju ki o to fa ipalara ẹdọfóró nla.Lẹhin wakati 1, LPS (5 mg / kg) ni itasi intracheal lati fa ipalara ẹdọfóró nla.Awọn eku deede ni a fun ni PBS [1].Awọn eku [2] lo awọn eku Wistar akọ (180-220g).Awọn eku ti pin laileto si awọn ẹgbẹ 4: ẹgbẹ iṣakoso, RIF ati ẹgbẹ INH, MAG kekere iwọn lilo ati ẹgbẹ iwọn giga MAG, pẹlu awọn eku 15 ni ẹgbẹ kọọkan.Awọn eku ni awọn ẹgbẹ RIF ati INH ni a fun ni RIF (60mg / kg) ati INH (60mg / kg) nipasẹ gavage lẹẹkan ni ọjọ kan;Awọn eku ni ẹgbẹ MAG ni a ṣe itọju pẹlu MAG ni iwọn lilo 45 tabi 90 mg / kg, ati RIF (60 mg / kg) ati INH (60 mg / kg) ni a fun ni awọn wakati 3 lẹhin iṣakoso MAG;Awọn eku ti o wa ninu ẹgbẹ iṣakoso ni a tọju pẹlu iyọ deede.Lati le ṣe iṣiro ipa agbara ti oogun naa, awọn eku ni ẹgbẹ kọọkan ni a pa ni ọjọ 7, 14 ati 21 lẹhin iṣakoso [2].
Itọkasi:1].Huang X, et al.Awọn Ipa Imudaniloju Alatako ti Monoammonium Glycyrrhizinate lori Lipopolysaccharide-Imubajẹ Ipalara Ẹdọfóró Nkan ninu Awọn eku nipasẹ Ṣiṣakoṣo Ipa-ipa Iparun-Kappa B Ọna Ifiranṣẹ.Evid orisun iranlowo Alternat Med.Ọdun 2015;2015:272474.
[2].Zhou L, et al.Monoammonium glycyrrhizinate ṣe aabo fun rifampicin- ati hepatotoxicity ti isoniazid nipasẹ ṣiṣe ilana ikosile ti gbigbe Mrp2, Ntcp, ati Oatp1a4 ninu ẹdọ.Pharm Biol.2016;54 (6): 931-7.
Awọn ohun-ini Kemikali ti Ammonium Glycyrrhizinate
iwuwo: 1.43g/cm
Ojutu farabale: 971.4 º C ni 760mmhg
Oju Iyọ: 209º C
Ilana molikula: c42h65no16
Iwọn Molikula: 839.96
Ojuami Filaṣi: 288.1º C
PSA: 272.70000
LogP: 0.32860
Irisi: funfun kirisita lulú
Atọka itọka: 49 ° (C = 1.5, EtOH)
Awọn ipo Ibi ipamọ: edidi ati fipamọ ni 2º C - 8º C
Iduroṣinṣin: ti o ba lo ati ti o fipamọ ni ibamu si awọn pato, kii yoo decompose ati pe ko si iṣesi ti o lewu ti a mọ
Solubility Omi: tiotuka die-die ninu omi, tiotuka laiyara pupọ ni ethanol anhydrous, ni iṣe tiotuka ni acetone O tuka ni awọn ojutu dilute ti acids ati ti alkali hydroxides.
Ammonium Glycyrrhizinate MSDS
Ammonium Glycyrrhizinate MSDS
1.1 ọja idamo
Ammonium Glycyrrhizinate wa lati gbongbo likorisi (likorisi)
Orukọ ọja
1.2 awọn ọna miiran ti idanimọ
Glycyrrhizin
3-O- (2-O- β- D-Glucopyranuronosyl- α- D-glucopyranuronosyl) -18 β- glycyrrhetinic acidammonium iyọ.
1.3 awọn lilo idanimọ ti o yẹ ti awọn nkan tabi awọn akojọpọ ati daba awọn lilo ti ko yẹ
Nikan fun awọn idi iwadi ijinle sayensi, kii ṣe gẹgẹbi awọn oogun, awọn oogun imurasilẹ idile tabi awọn idi miiran.
Alaye Aabo Ammonium Glycyrrhizinate
Awọn ohun elo aabo ti ara ẹni: awọn oju oju;Awọn ibọwọ;iru N95 (US);iru P1 (EN143) respirator àlẹmọ
Ewu koodu irinna: UN 3077 9 / pgiii
Wgk Germany: 2
RTECS No.: lz6500000
Igbaradi ti Ammonium Glycyrrhizinate
O le ṣe atunṣe pẹlu ethanol acid bi ohun elo aise.
Ammonium glycyrrhizinate litireso
Awọn amuaradagba HMGB1 ṣe akiyesi awọn sẹẹli carcinoma ọfin si iku sẹẹli ti o fa nipasẹ awọn aṣoju pro-apoptotic.
Int.J. Onkolu.46 (2), 667-76, (2014)
Awọn amuaradagba HMGB1 ni awọn iṣẹ lọpọlọpọ ninu isedale tumo ati pe o le ṣe mejeeji bi ifosiwewe transcription ati bi cytokine kan.HMGB1 ti wa ni idasilẹ lakoko iku sẹẹli, ati ninu awọn ẹkọ iṣaaju wa a ṣe afihan…
Imuṣiṣẹ TLR9 jẹ ma nfa nipasẹ ilokulo ti itunnu dipo awọn idinamọ ti o wa ninu Trypanosomatidae DNA.
Glycyrrhizin dinku yomijade HMGB1 ninu awọn sẹẹli RAW 264.7 ti o mu lipopolysaccharide ṣiṣẹ ati awọn eku endotoxemic nipasẹ p38/Nrf2-igbẹkẹle ti HO-1.
Int.Immunopharmacol.26, 112-8, (2015)
Apoti ẹgbẹ arinbo giga 1 (HMGB1) ni a mọ ni bayi bi olulaja pẹ ti sepsis.Botilẹjẹpe a mọ glycyrrhizin bi inhibitor ti HMGB1, ko tii ṣe afihan awọn ilana (s) ipilẹ.A rii pe glycemia…
English inagijẹ Ammonium glycyrrhizinate
GLYCAMIL
Ammonium glycynhizinato
iyọ monoammonium glycyrrhizic acid
ammonium glycyrrhizinate
MFCD00167400
Glycyrrhizin Monoammonium Iyọ Hydrate
Glycyrrhizic Acid Monoammonium Iyọ Hydrate
(3β) -30-Hydroxy-11,30-dioxoolean-12-en-3-yl 2-O-β-D-glucopyranuronosyl-a-D-glucopyranosiduronic acid diammoniate.
GLYCYRRHIZICAMONIUM
Magnasweet
amoniate
Monoammonium Glycyrrhizinate Hydrate
Glycyrrhizate monoammonium
