Cycloastragenol CAS No.. 78574-94-4
Ọja Specification
[orukọ]:cycloastragalus oti
[inagijẹ]:triterpenoid cyclic flavonol
[Orukọ Gẹẹsi]:cycloastragenol
[ agbekalẹ molikula]:C30H50O5
[iwuwo molikula]:490.71
[CAS No.]:78574-94-4
[ọna idanimọ]:HPLC ≥ 98%
[Ni pato]:20mg 50mg 100mg 500mg 1g (le ṣe akopọ gẹgẹbi awọn ibeere alabara)
[ohun-ini]:ọja yi jẹ kirisita acicular ti ko ni awọ
[iṣẹ ati lilo]:A lo ọja yii fun ipinnu akoonu, idanimọ, idanwo elegbogi, iṣayẹwo iṣẹ ṣiṣe ati awọn adanwo iwadii imọ-jinlẹ miiran.Gẹgẹbi iṣakoso sẹẹli, idanwo intragastric, ayewo didara inu ti ile-iṣẹ elegbogi, bbl Orisun: Astragalus membranaceus (Fisch.) Bge.Si dahùn o root jade
Ọna ipamọ
2-8 ° C, edidi lati ina ati fipamọ ni iwọn otutu kekere.
Akiyesi
Ọja yii yẹ ki o wa ni ipamọ ni iwọn otutu kekere.Ti o ba farahan si afẹfẹ fun igba pipẹ, akoonu yoo dinku.
Awọn ipo Chromatographic} ọwọn chromatographic: Zorbax rx-c18 (4.6mm) × 150mm) ， 5 μ m； Ipele alagbeka: omi acetonitrile (30:70);Oṣuwọn sisan: 1.0ml/min, iwọn otutu iwe: 35 ℃, ELSD paramita: drift tube otutu: 105 ℃, nitrogen sisan oṣuwọn: 2.70ml/min.
Awọn ohun-ini ti kemikali: iwuwo 1.20
Bioactivity ti cycloastragenol
Cycloastragalol jẹ triterpene saponin yellow, eyiti o jẹ Astragalus membranaceus (Fisch.) Awọn hydrolyzate ti eroja ti nṣiṣe lọwọ ni Bunge).Astramembrangenin ni aabo ẹnu ati pe o ni ọpọlọpọ awọn ipa elegbogi, pẹlu imuṣiṣẹ telomerase, imuduro telomere, egboogi-iredodo ati awọn ohun-ini antioxidant.Astramembrangenin ni awọn ohun-ini egboogi-ti ogbo.CAG ṣe iwuri iṣẹ telomerase ninu awọn keratinocytes ọmọ tuntun ti eniyan ati awọn sẹẹli nafu eku ati fa imuṣiṣẹ CREB.Astramembrangenin le ni ipa iwosan tuntun ni ibanujẹ
Awọn ẹka to wulo:
Ona ifihan agbara > > apoptosis > > apoptosis
Aaye iwadi > > igbona / ajesara
Aaye iwadi > Awọn arun iṣan
Ninu Ikẹkọ Vitro:
Ti a ṣe afiwe pẹlu iṣakoso ti ngbe ni aṣa HEK, amuaradagba awo irawo (0-10 μM; 3-6 ọjọ) pọ si idagbasoke sẹẹli [1].Astramembrangenin (0.3 μ M;Awọn iṣẹju 5-90) ti fa phosphorylation CREB ni awọn neurons cortical akọkọ, ati ikosile ti lapapọ CREB ni awọn iru sẹẹli mejeeji ko ni ipa nipasẹ CAG [1].amuaradagba awo awo irawọ (3) μ M;Awọn wakati 6-48) le ṣe igbega ni ifihan ifihan vivo ni awọn neuronu, mu ikosile TERT mRNA pọ si, ati ṣafihan ikosile bcl 2 mRNA ti o pọ si [1].Iwadii ṣiṣeeṣe sẹẹli [1] laini sẹẹli: Ifojusi sẹẹli HEK: 1 μ M，3 μM，10 μM akoko aṣa: Awọn abajade ọjọ 3-6: idagba sẹẹli ti ilọpo meji ni ọjọ mẹfa.Itupalẹ abawọn Western blot [1] laini sẹẹli: ifọkansi sẹẹli neuron: 0.3 μM akoko asa: iṣẹju 5, iṣẹju 15, iṣẹju 30, iṣẹju 90.Awọn abajade: CAG mu ṣiṣẹ CREB ni awọn neuronu.RT-PCR [1] laini sẹẹli: ifọkansi sẹẹli neuron: 3 μM akoko asa: awọn abajade wakati 6-48: ikosile ti TERT ati Bcl 2 mRNA pọ si.
Itọkasi:
[1].Ip FC, et al.Cycloastragenol jẹ oluṣeto telomerase ti o lagbara ninu awọn sẹẹli neuronal: awọn ipa fun iṣakoso ibanujẹ.Neurosignals.2014;22 (1): 52-63.
[2].Yu Y, et al.Cycloastragenol: Oludije aramada moriwu fun awọn arun ti o ni ibatan ọjọ-ori.Exp Ther Med.2018 Oṣu Kẹsan; 16 (3): 2175-2182.
[3].Sun C, et al.Cycloastragenol ṣe agbedemeji imuṣiṣẹ ati idinku imudara ni concanavalin A-induced mouse lymphocyte pan-activation model.Immunopharmacol Immunotoxicol.2017 Jun; 39 (3): 131-139.
Awọn ohun-ini Kemikali ti Cycloastragenol
Ìwúwo:1,2 ± 0,1 g / cm3
Oju ibi farabale:617.2 ± 55.0 ° C ni 760 mmHg
Ibi yo:241.0 si 245,0 ° C
Ilana molikula:c30h50o5
Ìwúwo molikula:490.715
Oju filaṣi:327,1 ± 31,5 ° C
Iwọn gangan:490.365814
PSA:90.15000
LogP:3.82
Titẹ nya si:0.0 ± 4.0 mmHg ni 25 ° C
Atọka itọka:1.582
Cycloastragenol Alaye Abo
Koodu gbigbe ti awọn ẹru ti o lewu: noh fun gbogbo awọn ọna gbigbe
Nọmba RTECS;GX8265000
koodu kọsitọmu: 2942000000
Awọn kọsitọmu Cycloastragalol
koodu kọsitọmu: 2942000000
Cycloastragalol Literature
Cycloastragenol jẹ oluṣeto telomerase ti o lagbara ninu awọn sẹẹli neuronal: awọn ipa fun iṣakoso ibanujẹ.
Awọn ifihan agbara Neuro 22 (1), 52-63, (2014)
Cycloastragenol (CAG) jẹ aglycone ti astragaloside IV.A kọkọ ṣe idanimọ rẹ nigbati iboju Astragalus membranaceus jade fun awọn eroja ti nṣiṣe lọwọ pẹlu awọn ohun-ini antiaging.Iwadi lọwọlọwọ de ...
Ara aramada telomerase activator dinku ibajẹ ẹdọfóró ni awoṣe murine ti fibrosis ẹdọforo idiopathic.
PLoS ỌKAN 8 (3), e58423, (2013)
Ifarahan ti awọn arun ti o ni nkan ṣe pẹlu aiṣedeede telomere, pẹlu AIDS, ẹjẹ aplastic ati fibrosis ẹdọforo, ti ṣe alekun iwulo ninu awọn activators telomerase.A ṣe ijabọ idanimọ ti n...
Imudara elegbogi orisun Telomerase ti iṣẹ antiviral ti CD8+ T lymphocytes eniyan.
J. Immunol.181 (10), 7400-6, (2008)
Telomerase reverse ṣe atunkọ DNA telomere si awọn opin ti awọn krómósómù laini ati ki o fahinti ogbo cellular.Ni idakeji si ọpọlọpọ awọn sẹẹli somatic deede, eyiti o fihan diẹ tabi ko si iṣẹ telomerase, ajesara…
English inagijẹ ti Cycloastragalol
9,19-Cyclolanostane-3,6,16,25-tetrol,20,24-epoxy-,(3β,6α,9β,16β,20R,24S)-
Astramembrangenin
(3β,6α,9β,16β,20R,24R) -20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol
19-Cyclolanostane-3,6,16,25-tetrol,20,24-epoxy-,(3β,6α,9β,16β,20R,24R)-
(3β,6α,9β,16β,20R,24S)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol
Cyclosieversigenin
Cyclogalegigenin
