Danshensu
Ọja Specification
Orukọ ti o wọpọ:Danshensu
CAS No.:76822-21-4
Ìwúwo:1,5 ± 0,1 g / cm3
Fọọmu Molecular:C9H10O5
MSDS:n / aaye filasi: 259.1 ± 23.8 ° C
Orukọ Gẹẹsi:Danshensu
Ìwọ̀n Molikula:198.17
Oju Ise:198.17
Oju Iyọ:N/A
Orukọ Danshensu
Orukọ Kannada:Danshensu
Orukọ Gẹẹsi:(2R) - 3 - (3,4-dihydroxyphenyl) - 2-hydroxypropanoic acid
Apejẹ Kannada:B - (3,4-dihydroxyphenyl) lactic acid |cryptotanshinone |B - (3.4-dihydroxyphenyl) lactic acid
Danshensu bioactivity
Apejuwe:Danshensu jẹ ẹya ti o munadoko ti Salvia miltiorrhiza, eyiti o le mu ipa ọna ifihan Nrf2 ṣiṣẹ ati daabobo eto inu ọkan ati ẹjẹ.
Awọn ẹka ti o jọmọ: ipa ọna ifihan > > autophagy > > autophagy
Ona ifihan agbara> NF-κ B ọna ifihan agbara> keap1-nrf2
Aaye iwadi > > Arun inu ọkan ati ẹjẹ
Awọn ọja Adayeba >> benzoic acids
Ninu Ikẹkọ Vitro:Danshensu (DSS) dinku ni pataki awọn ipele ti awọn ensaemusi asami (creatine kinase ati lactate dehydrogenase) ti iṣan iṣan ẹjẹ ati iwọn infarction myocardial.Eyi le ṣe igbelaruge imularada ti iṣẹ ọkan ọkan lẹhin ipalara I / R.DSS tun ni iṣẹ ṣiṣe scavenging ROS ati igbega iṣẹ ṣiṣe ti awọn antioxidants endogenous gẹgẹbi SOD, cat, MDA, GSH-Px ati HO-1 nipa mimuuṣiṣẹpọ ifosiwewe iparun erythrocyte-2 ti o ni ibatan ifosiwewe 2 (Nrf2) ipa ọna ifihan agbara nipasẹ Akt ati ERK1.2 ni Itupalẹ abawọn Oorun [2].
Ninu Ikẹkọ Vivo:itọju nla pẹlu iwọn lilo kan ti Danshensu ko yipada pilasima tHcy ninu awọn eku pẹlu tHcy deede.Ni idakeji, Danshensu dinku tHcy ni pataki ninu awọn eku pẹlu tHcy ti o ga.Awọn ipele ti o ga julọ ti cysteine ati glutathione lẹhin itọju Danshensu fihan pe ipa rẹ ti idinku tHcy jẹ nipasẹ jijẹ iṣẹ ṣiṣe ti ipa ọna vulcanization trans [1].
Awọn idanwo ẹranko:gbogbo awọn kemikali ti wa ni tituka ni iyọ ayafi tolcapone tituka ninu iyọ ti o ni 20% (V / V) peg 200. Lakoko idanwo naa, awọn eku ti gbawẹ ni alẹ ati laileto sọtọ si awọn ẹgbẹ oriṣiriṣi.Lẹhin akuniloorun ether, nipa 200 ni a yọ kuro lati inu orbital sinus μ L ẹjẹ, lẹhinna yarayara disinfect pẹlu ọti-waini ati tẹ pẹlu owu.Awọn ayẹwo ẹjẹ ni a gba lẹsẹkẹsẹ sinu awọn tubes polypropylene ti o ni iṣuu soda heparin ati centrifuged ni 5000 g ni 5 ° C fun awọn iṣẹju 3.Awọn ayẹwo pilasima ti a pese silẹ ni a tọju ni -20 ℃ ati itupalẹ laarin awọn wakati 48.
Awọn itọkasi:[1] YG Cao, et al.Awọn ipa anfani ti danshensu, paati ti nṣiṣe lọwọ ti Salvia miltiorrhiza, lori iṣelọpọ homocysteine nipasẹ ọna trans-sulphuration ninu awọn eku.Br J Pharmacol.Ọdun 2009 Oṣu Kẹta;157 (3): 482–490.
[2].Yu J, et al.Danshensu ṣe aabo ọkan ti o ya sọtọ lodi si ipalara ischemia reperfusion nipasẹ ṣiṣiṣẹ ti ifihan Akt/ERK1/2/Nrf2.Int J Clin Exp Med.Ọdun 2015 Oṣu Kẹsan 15;8 (9): 14793-804.
Awọn ohun-ini kẹmika ti Danshensu
Ìwúwo:1,5 ± 0,1 g / cm3
Fọọmu Molecular:C9H10O5
Oju filaṣi:259,1 ± 23,8 ° C
LogP:- 0.29
Atọka Refractive:1.659
Oju Ise:481.5 ± 40.0 ° C ni 760 mmHg
Ìwọ̀n Molikula:198.17
PSA:97.99000
Titẹ Nya si:0.0 ± 1.3 mmHg ni 25 ° C
Danshensu Alaye Abo
koodu kọsitọmu: 2942000000
English inagijẹ ti Danshensu
Danshensu
Iṣuu soda (2R) -3- (3,4-dihydroxyphenyl) -2-hydroxypropanoate
(2R) -3- (3,4-Dihydroxyphenyl) -2-hydroxypropanoic acid
Benzenepropanoic acid, α,3,4-trihydroxy-, (αR)
Benzenepropanoic acid, α,3,4-trihydroxy-, iyọ soda, (αR)- (1:1)
Salvianic
