Neohesperidin
Ohun elo ti Synephrine Hydrochloride
Neohesperidin jẹ iru idapọ flavonoid kan ti o wa ni ibigbogbo ni awọn ohun ọgbin Cucurbitaceae ati pe o ni ẹda-ara ati awọn ipa-iredodo./h2>
Orukọ Neohesperidin
Orukọ Gẹẹsi: neohesperidin
Chinese inagijẹ: neohesperidin |neohesperidin
Bioactivity ti Neohesperidin
Apejuwe: neohesperidin jẹ agbo-ara flavonoid ti a rii ni Cucurbitaceae, eyiti o ni awọn ipa ti o ni ẹda ati awọn ipa-iredodo.
Awọn ẹka ti o jọmọ: Ona ifihan agbara > > miiran > > miiran
aaye iwadi > > igbona / ajesara
adayeba Products > > flavonoids
Ninu Ikẹkọ Vitro:
Hesperidin tuntun nfa apoptosis sinu akàn igbaya eniyan MDA-MB-231 awọn sẹẹli.Awọn iye IC50 ti neohesperidin ni awọn wakati 24 ati 48 jẹ 47.4 ± 2.6, lẹsẹsẹ μ M ati 32.5 ± 1.8 μ M. Ọrọ ti p53 ati Bax ti ṣe ilana ni pataki ni awọn sẹẹli itọju neohesperidin, lakoko ti ikosile ti Bcl-2 wa ni isalẹ. ofin [1].Neohesperidin ṣe afihan iṣẹ-ṣiṣe antioxidant ni idanwo radical DPPH (IC50 = 22.31 μ g / mL) [2].
Ninu Ikẹkọ Vivo: neohesperidin (50mg / kg) ṣe idiwọ ni pataki 55.0% HCl / ethanol ti o fa ipalara ikun.Ninu awọn eku ligated pylorus, neohesperidin (50 miligiramu / kg) dinku ifasilẹ inu ni pataki ati iṣelọpọ acid inu ati alekun pH [1].Itọju Neohesperidin ṣe pataki dinku glukosi ẹjẹ ãwẹ, glukosi ẹjẹ ati amuaradagba omi ara glycosylated (GSP) ninu awọn eku.O pọ si ni pataki ifarada glukosi ẹnu ati ifamọ insulin, ati dinku resistance insulin ninu awọn eku alakan.Neohesperidin dinku pataki awọn triglycerides omi ara, idaabobo awọ lapapọ, awọn ipele leptin ati atọka ẹdọ ninu awọn eku [3].
Idanwo Ẹranko: eku: Gbogbo awọn eku ti gbawẹ ni wakati mẹfa ṣaaju idanwo naa, lẹhinna wọn jẹ pẹlu omi tabi neohesperidin nipasẹ ifunni fipa mu.Fun OGTT ati ITT, awọn eku ni abẹrẹ intraperitoneally pẹlu 2G / kg BW glucose tabi 1iu / kg insulini BW, lẹsẹsẹ.Awọn ayẹwo ẹjẹ ni a gba lati iṣọn caudal lati wiwọn awọn ipele glukosi ẹjẹ basali (iṣẹju 0) ṣaaju abẹrẹ ti glukosi tabi hisulini.Awọn ipele glukosi ẹjẹ ni afikun ni a wọn ni 30, 60, 90 ati 120 iṣẹju [3].
Itọkasi:[1].Lee JH, et al.Awọn ipa aabo ti neohesperidin ati poncirin ti o ya sọtọ lati awọn eso ti Poncirus trifoliata lori arun inu ti o pọju.Phytother Res.2009 Oṣu kejila; 23 (12): 1748-53.
[2].Xu F, et al.Neohesperidin nfa apoptosis cellular ni adenocarcinoma igbaya eniyan MDA-MB-231 awọn sẹẹli nipasẹ mimuuṣiṣẹpọ Bcl-2/Bax-mediated signaling path.Nat Prod Commun.Ọdun 2012; 7 (11): 1475-8.
[3].Jia S, et al.Hypoglycemic ati awọn ipa hypolipidemic ti neohesperidin ti o wa lati Citrus aurantium L. ninu awọn eku KK-A (y) dayabetik.Ounjẹ Iṣẹ.2015 Mar; 6 (3): 878-86.
Awọn ohun-ini Kemikali ti Neohesperidin
iwuwo: 1.7 ± 0.1 g / cm3
Ojuami Sise: 933.7 ± 65.0 ° C ni 760 mmHg
Oju Iyọ: 239-243ºC
Ilana molikula: C28H34O15
Iwọn Molikula: 610.561
Ojuami Filasi: 306.7 ± 27.8 ° C
Gangan Ibi: 610.189758
PSA: 234.29000
LogP:2.44
Irisi: 0.0 ± 0.3 mmHg ni 25 ° C
Titẹ Nya si: 0.0 ± 0.3 mmHg ni 25 ° C
Atọka itọka: 1.695
Awọn ipo ipamọ: 2-8 ° C
Titun Hesperidin Aabo Alaye
Awọn ohun elo aabo ti ara ẹni: awọn oju oju;Awọn ibọwọ;iru N95 (US);iru P1 (EN143) respirator àlẹmọ
Gbólóhùn Aabo (Europe): s22-s24 / 25
Koodu gbigbe ti awọn ẹru ti o lewu: noh fun gbogbo awọn ọna gbigbe
Wgk Germany: 3
RTECS No.: dj2981400
Neohesperidin Literature
Ifiwera ti iṣelọpọ agbara ati itupale transcriptional ti diploid ilọpo meji ati diploid citrus rootstock rẹ (C. junos cv. Ziyang xiangcheng) ni imọran iye ti o pọju fun ilọsiwaju resistance aapọn.
BMC ọgbin Biol.15, 89, (2015)
Polyploidy ni igbagbogbo ni a gbero lati fun awọn irugbin ni isọdọtun ti o dara julọ si awọn aapọn ayika.Awọn rootstocks citrus Tetraploid ni a nireti lati ni ifarada wahala ti o lagbara ju diploid.Opolopo re...
Ougan (Citrus reticulata cv. Suavissima) flavedo jade kuro ni motility akàn nipasẹ kikọlu pẹlu iyipada epithelial-to-mesenchymal ni awọn sẹẹli SKOV3.
Gban.Med.10, 14, (2015)
Ougan (Citrus reticulata cv. Suavissima) flavedo jade (OFE) ṣe afihan awọn ipa ipakokoro-itumọ ti o pọju pẹlu awọn ilana ti o wa labẹ koyewa.Iwadi yii ni ero lati ṣe iṣiro agbara anti-metastatic acti...
Hesperidin, nobiletin, ati tangeretin jẹ iduro lapapọ fun agbara egboogi-neuroinflammatory ti peeli tangerine (Citri reticulatae pericarpium).
Ounjẹ Chem.Toxikol.Ọdun 71, ọdun 176-82, (2014)
Idinamọ microglial imuṣiṣẹ-ara-ara neuroinflammation ti di ibi-afẹde idaniloju fun idagbasoke awọn ounjẹ iṣẹ-ṣiṣe lati ṣe itọju awọn arun neurodegenerative.Peeli Tangerine (Citri reticulata...
English inagijẹ Of Neohesperidin
HESPERETIN-7-NEOHESPERIDOSIDE
Hesperetin7-neohesperidoside
4H-1-Benzopyran-4-ọkan, 7-[[2-O- (6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl] oxy]-2,3-dihydro-5-hydroxy-2 -(3-hydroxy-4-methoxyphenyl)-, (2S)
(2S) -5-Hydroxy-2- (3-hydroxy-4-methoxyphenyl) -4-oxo-3,4-dihydro-2H-chromen-7-yl 2-O- (6-deoxy-α-L- mannopyranosyl) -β-D-glucopyranoside
hesperetin 7-O-neohesperoside
Neohesperdin
Neohesperdin
MFCD00017357
Hesperetin-7-O-neohesperidoside
EINECS 236-216-9
(S) -4'-Methoxy-3',5,7-trihydroxyflavanone-7-[2-O- (α-L-rhamnopyranosyl)-β-D-glucopyranoside]
4H-1-Benzopyran-4-ọkan, 2,3-dihydro-7-(2-O- (6-deoxy-a-L-mannopyranosyl)-β-D-glucopyranosyl) oxy) -5-hydroxy-2 -(3-hydroxy-4-methoxyphenyl)-, (S)
Hesperetin 7-O-neohesperidoside
