Obtusin
Lilo ti Obtusin
Obtusin, lati inu irugbin cassia, jẹ oludaniloju to ga julọ ati ifigagbaga ti monoamine oxidase-A (hmao-a), pẹlu IC50 ti 11.12 μ M. Ki jẹ 6.15.Obtusin ṣe ipa idena ninu awọn aarun neurodegenerative, paapaa aibalẹ ati aibalẹ.
Orukọ Obtusin
Orukọ Gẹẹsi: Obtusin
Bioactivity ti Obtusin
Apejuwe: obtusin wa lati irugbin cassia.O jẹ oludaniloju ti o yan pupọ ati ifigagbaga ti monoamine oxidase-A (hmao-a), pẹlu IC50 ti 11.12 μ M. Ki jẹ 6.15.Obtusin ṣe ipa idena ninu awọn aarun neurodegenerative, paapaa aibalẹ ati aibalẹ.
Awọn ẹka ti o jọmọ: Ona ifihan agbara>> Ona ifihan agbara nkankikan>> monoamine oxidase
Aaye iwadi > Awọn arun iṣan
Àfojúsùn: IC50: 11.12 μ M (hMAO-A) [1] Ki: 6.15 (hMAO-A) [1]
Awọn itọkasi: [1] Paulel P, et al.Ni Vitro ati ni Silico Human Monoamine Oxidase Inhibitory Agbara ti Anthraquinones, Naphthopyrones, ati Naphthalenic Lactones lati Cassia obtusifolia Linn Awọn irugbin.ACS Omega.Oṣu Kẹsan 18, ọdun 2019;4 (14): 16139-16152.
Awọn ohun-ini imọ-ẹrọ ti Obtusin
iwuwo: 1.4 ± 0.1 g / cm3
Ojuami Sise: 614.9 ± 55.0 ° C ni 760 mmHg
Ilana molikula: c18h16o7
Iwọn Molikula: 344.315
Ojuami Filasi: 227.0 ± 25.0 ° C
Gangan Ibi: 344.089600
PSA: 102.29000
LogP: 4.10
Titẹ Nya si: 0.0 ± 1.8 mmHg ni 25 ° C
Atọka itọka: 1.634
Obtusin Aabo Alaye
koodu kọsitọmu: 2914690090
Literature: Cameron, Donald W;Feutrill, Geoffrey I.;Gamble, Glenn B.;Stavrakis, John Tetrahedron Awọn lẹta, 1986, vol.27, # 41 ojú ìwé.4999-5002
Obtusin kọsitọmu
koodu kọsitọmu: 2914690090
Chinese Akopọ: Chinese Akopọ
Lakotan: 2914690090 awọn quinones miiran
English inagijẹ Of kọsitọmu
9,10-Anthracenedione, 1,7-dihydroxy-2,3,8-trimethoxy-6-methyl-
1,7-dihydroxy-2,3,8-trimethoxy-6-methylanthracene-9,10-dione
1,7-Dihydroxy-2,3,8-trimethoxy-6-methyl-9,10-anthraquinone
Iṣakoso Didara ọja
1. Awọn ile-ra iparun se resonance (Bruker 400MHz) spectrometer, omi ipele ibi-spectrometer (LCMS), gaasi ipele ibi-spectrometer (GCMs), ibi-spectrometer (omi SQD), ọpọ laifọwọyi analitikali ga išẹ omi chromatographs, igbaradi omi chromatographs, ati be be lo. .
2. Ile-iṣẹ n ṣetọju ifowosowopo sunmọ ati olubasọrọ pẹlu awọn ile-iṣẹ iwadi ijinle sayensi gẹgẹbi Shanghai Institute fun iṣakoso oògùn, Nanjing biomedical public service platform and analysis and test center of Shanghai Pharmaceutical Industry Research Institute.
3. Ile-iṣẹ naa n ṣiṣẹ ni agbara lati ṣe iwe-ẹri idanwo ẹni-kẹta yàrá, ati pe a nireti lati gba Iwe-ẹri Ifọwọsi yàrá CNAs ni 2021.
