Salvianolic acid C
Idi
Salvianolic acid C jẹ inhibitor ti kii ṣe ifigagbaga ti cytochrome p4502c8 (cyp2c8) ati inhibitor adalu ti cytochrome P4502J2 (CYP2J2) pẹlu kikankikan alabọde.Awọn iye Ki rẹ fun cyp2c8 ati CYP2J2 jẹ 4.82 lẹsẹsẹ μ M ati 5.75 μM
Orukọ Gẹẹsi
(2R) -3- (3,4-Dihydroxyphenyl) -2- ({(2E) -3-[2- (3,4-dihydroxyphenyl)- 7-hydroxy-1-benzofuran-4-yl]-2- propenoyl}oxy) propanoic acid
English inagijẹ
(2R) -3- (3,4-Dihydroxyphenyl) -2- ({(2E) -3-[2- (3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl] prop-2 -enoyl}oxy) propanoic acid
(2R) -3- (3,4-Dihydroxyphenyl) -2- ({(2E) -3-[2- (3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]-2- propenoyl}oxy) propanoic acid
Benzenepropanoic acid, α-[[(2E) -3-[2- (3,4-dihydroxyphenyl) -7-hydroxy-4-benzofuranyl]-1-oxo-2-propen-1-yl] oxy] -3, 4-dihydroxy-, (αR)-
Salvianolic acid C
Awọn ohun-ini Kemikali ti Salvianolic Acid C
iwuwo: 1.6 ± 0.1 g / cm3
Ojuami Sise: 844.2 ± 65.0 ° C ni 760 mmHg
Ilana molikula: C26H20O10
Iwọn Molikula: 492.431
Filasi ojuami: 464,4 ± 34,3 ° C
Gangan Ibi: 492.105652
PSA: 177.89000
Wọle: 3.12
Titẹ Nya si: 0.0 ± 3.3 mmHg ni 25 ° C
Atọka itọka: 1.752
Bioactivity ti Salvianolic Acid C
Apejuwe:
Salvianolic acid C jẹ inhibitor ti kii ṣe ifigagbaga ti cytochrome p4502c8 (cyp2c8) ati inhibitor adalu ti cytochrome P4502J2 (CYP2J2) pẹlu kikankikan alabọde.Awọn iye Ki rẹ fun cyp2c8 ati CYP2J2 jẹ 4.82 lẹsẹsẹ μ M ati 5.75 μM.
Awọn ẹka to wulo:
Ona ifihan agbara>> henensiamu ti iṣelọpọ / protease>> cytochrome P450
Aaye iwadi > > akàn
Awọn ọja adayeba > > awọn miiran
Àfojúsùn:
CYP2C8: 4.82 μM (Ki)
CYP2J2:5.75 μM (Ki)
Ninu Ikẹkọ Vitro:
Salvianolic acid C jẹ inhibitor alapọpo iwọntunwọnsi ti inhibitor cyp2c8 ti ko ni idije ati CYP2J2.KIS ti cyp2c8 ati CYP2J2 jẹ 4.82 ati 5.75 lẹsẹsẹ μ M[1].Salvianolic acid C ṣe pataki dinku ikosile ti iNOS.Salvianolic acid C ṣe idiwọ LPS ti o fa TNF-a, IL-1 β, IL-6 ati IL-10 ti mujade lọpọlọpọ.Salvianolic acid C ṣe idiwọ imuṣiṣẹ LPS NF-κ B ṣiṣẹ.Salvianolic acid C tun pọ si ikosile ti Nrf2 ati HO-1 ni BV2 microglia [2].
Ninu awọn ẹkọ Vivo:
Itọju Salvianolic acid C (20mg / kg) dinku lairi ona abayo ni pataki.Ni afikun, itọju SALC (10 ati 20 miligiramu / kg) pọ si ni pataki nọmba awọn irekọja Syeed ni akawe pẹlu ẹgbẹ awoṣe LPS.Ti a ṣe afiwe pẹlu ẹgbẹ awoṣe, iṣakoso eto eto ti salvianolic acid C si isalẹ ọpọlọ TNF-a, IL-1 β Ati awọn ipele IL-6.Awọn ipele ti iNOS ati COX-2 ni cortex cerebral ati hippocampus ti awọn eku jẹ ti o ga ju awọn ti o wa ninu ẹgbẹ iṣakoso, lakoko ti itọju salvianolic acid C ṣe pataki si isalẹ awọn ilana cortex ati hippocampus.Salvianolic acid C (5, 10 ati 20 mg / kg) itọju pọ si p-ampk, Nrf2, HO-1 ati awọn ipele NQO1 ni kotesi cerebral eku ati hippocampus ni ọna ti o gbẹkẹle iwọn lilo [2].
Itọkasi:
[1].Xu MJ, et al.Awọn ipadanu ti awọn paati Danshen lori CYP2C8 ati CYP2J2.Chem Biol Interact.2018 Oṣu Kẹjọ 1;289:15-22.
[2].Orin J, et al.Imuṣiṣẹ ti Nrf2 ifihan agbara nipasẹ salvianolic acid C attenuates NF κ B ti o ni ifarabalẹ iredodo ti o ni ipa mejeeji ni vivo ati in vitro.Int Immunopharmacol.Ọdun 2018;63:299-310.
