I-3-Hydroxy-9,10-dimethoxyptercarpan ehamba phambili,I-Methylnissolin Umkhiqizi kanye Nemboni |I-Yongjian

3-Hydroxy-9,10-dimethoxyptercarpan,Methylnissolin

Incazelo emfushane:

Igama Elivamile: Isici esibomvu se-sandalwood se-Meidi

Igama lesiNgisi: methylnissolin

Inombolo ye-CAS: 73340-41-7

Isisindo se-Molecular: 300.306

Ukuminyana: 1.3 ± 0.1 g / cm3

Indawo yokubilisa: 428.9 ± 45.0 ° C ku-760 mmHg

I-Molecular Formula: C17H16O5

I-Melting Point: nN/ A

I-MSDS: N/A

I-Flash Point: 213.2 ± 28.7 ° C

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Ukusetshenziswa kweMethylnissolin

I-Methylnisolin (astrapterocarpan) ihlukaniswe ne-Astragalus membranaceus futhi ingavimbela ukwanda kwamaseli okubangelwa yi-platelet-derived growth factor (PDGF) - BB, ene-IC50 ye-10 μ M. 2) i-mitogen activated protein (imephu) kinase eyenziwe yi-PDGF-BB.I-Methylnisolin ivimbela i-PDGF-BB eyenza ukwanda kwamaseli emisipha abushelelezi emithanjeni ngokuvimbela i-ERK1 / 2 MAP kinase cascade.

Igama leMethylnissolin

Igama lesiNgisi:

(-)-6aR,11aR-dihydro-3-hydroxy-9,10-dimethoxy-6H-benzofuro[3,2-c][1]-benzopyran

Isibizo sesiShayina: 3-hydroxy-9,10-dimethoxy red sandalwood |I-Astragalus ebomvu

i-sandalwood |(6aR, 11ar) - 3-hydroxy-9,10-dimethoxy red sandalwood

Umsebenzi Webhayoloji weMethylnissolin

Incazelo: I-methylnisolin (astrapterocarpan) ihlukaniswe ne-Astragalus membranaceus

futhi ingavimbela ukwanda kwamaseli okubangelwa yi-platelet-derived growth factor (PDGF) - BB.

I-IC50 ingu-10 μ M. I-Methylnisolin ivimbela i-phosphorylation yesiginali ye-extracellular

i-regulated kinase 1 / 2 (eric1 / 2) i-mitogen activated protein (imephu) kinase eyenziwe ngu

I-PDGF-BB.I-Methylnisolin ivimbela i-PDGF-BB eyenza ukwanda kwe-vascular smooth

amaseli emisipha ngokuvimbela i-ERK1 / 2 MAP kinase cascade.

Izigaba Ezihlobene: inkundla yocwaningo > > isifo senhliziyo

indlela yesignali > > protein tyrosine kinase > > PDGFR

indlela yesignali > > MAPK / ERK indlela yesiginali > > ERK

indlela yokusayina > > ama-stem cells kanye nendlela ye-Wnt > > ERK

I-Trait:PDGFR:10 μM (IC50)

ERK1

ERK2

Inkomba:[1].U-Ohkawara S, et al.I-Astrapterocarpan ehlukanisiwe ne-Astragalus membranaceus ivimbela ukwanda kwamaseli emisipha abushelelezi emithambo.Eur J Pharmacol.2005 Nov 21;525(1-3):41-7.

Izakhiwo ze-Physicochemical of Methylnissolin

Ukuminyana: 1.3 ± 0.1 g / cm3

Indawo yokubilisa: 428.9 ± 45.0 ° C ku-760 mmHg

I-Molecular Formula: c17h16o5

Isisindo se-Molecular: 300.306

I-Flash Point: 213.2 ± 28.7 ° C

IMisa Elinembile: 300.099762

I-PSA: 57.15000

I-logP:2.45

I-Steam Pressure: 0.0 ± 1.1 mmHg ku-25 ° C

Inkomba ye-Refractive: 1.612

I-Jiangsu Yongjian Pharmaceutical Technology Co., Ltd.

I-Jiangsu Yongjian Pharmaceutical Technology Co., Ltd., eyasungulwa ngoMashi 2012, iyibhizinisi lobuchwepheshe obuphezulu elihlanganisa i-R & D, ukukhiqiza nokudayisa.Isebenza kakhulu ekukhiqizeni, ukwenza ngokwezifiso kanye nenqubo yokukhiqiza ukuthuthukiswa kwezingxenye ezisebenzayo zemikhiqizo yemvelo, izinto zokubhekisela zemithi yendabuko yamaShayina kanye nokungcola kwezidakamizwa.Le nkampani itholakala e-China Pharmaceutical City, eDolobheni laseTaizhou, eSifundazweni saseJiangsu, okuhlanganisa nesizinda sokukhiqiza esingamamitha-skwele angu-5000 kanye nesisekelo se-R & D esingamamitha-skwele angu-2000.Isebenza ikakhulukazi izikhungo ezinkulu zocwaningo lwesayensi, amanyuvesi kanye namabhizinisi okukhiqiza izingcezu ze-decoction ezweni lonke.

Kuze kube manje, sesithuthukise izinhlobo ezingaphezu kuka-1500 zama-reagents emvelo, futhi saqhathanisa futhi salinganisa izinhlobo ezingaphezu kuka-300 zezinto zokubhekisela, ezingahlangabezana ngokugcwele nezidingo zokuhlolwa kwansuku zonke zezikhungo ezinkulu zocwaningo lwesayensi, ama-laboratories asenyuvesi kanye namabhizinisi okukhiqiza izingcezu ze-decoction.

Ngokusekelwe kumgomo wokholo oluhle, inkampani inethemba lokubambisana ngobuqotho namakhasimende ethu.Inhloso yethu wukusebenzela ukwenziwa kwesimanjemanje kwemithi yendabuko yamaShayina.