I-Benzoylpaeoniflorin
Ukucaciswa Komkhiqizo
OkuvamileIgama: benzoyl paeoniflorin
Inombolo ye-CAS:38642-49-8
Igama lesiNgisi:i-benzoylpaeoniflorin
Isisindo se-Molecular:584.568
Ukuminyana:1.6 ± 0.1 g / cm3 iphoyinti elibilayo: 742.9 ± 60.0 ° C ku-760 mmHg
Ifomula ye-molecular:c30h32o12 indawo encibilikayo: n / A
I-MSDS: n / i-flash point: 243.1 ± 26.4 ° C
Umsebenzi Wezinto Eziphilayo We-Benzoyl paeoniflorin
Incazelo:I-benzoylpaeoniflorin iyinhlanganisela yemvelo, okubikwa ukuthi yelapha isifo senhliziyo ngokunciphisa i-apoptosis.
Izigaba Ezihlobene:indlela yesignali > > enye > > enye
Imikhiqizo yemvelo > > ama-terpenoids nama-glycosides
Umkhakha wocwaningo > > isifo senhliziyo
Ireferensi:[1].Xinfeng Zhao, et al.Ukunqunywa Kwesilinganiso Nekhwalithi Kwamathebulethi e-Liuwei Dihuang nge-HPLC–UV-MS–MS.Ijenali yeChromatographic Science, Umq.45, Septhemba 2007, 549-552
[2].U-ZHANG Er-li, et al.Imiphumela ye-Benzoylpaeoniflorin ku-apoptosis yamagundane ane-Coronary Heart Diseases.Ijenali yaseShayina Yokuxilongwa Kwelabhorethri, 2011-04.
Izakhiwo ze-Physicochemical ze-benzoyl paeoniflorin
Ukuminyana:1.6 ± 0.1 g / cm3
Indawo yokubilisa:742.9 ± 60.0 ° C ku-760 mmHg
I-Molecular Formula:I-C30H32O12
Isisindo se-Molecular:584.568
I-Flash Point:243.1 ± 26.4 °
Imisa Enembile:584.189392
I-PSA:170.44000 LogP:5.55
Umfutho we-vapor:0.0 ± 2.6 mmHg ku-25 ° C
I-Refractive Index:1.682
Igama LesiNgisi Le-Benzoylpaeoniflorin
{(3S,5R,6S)-1-({[(4,5-Dihydroxy-2-cyclohexen-1-yl)carbonyl]oxy}methyl)-3-[(1aR)-1H-3,4-dioxacyclobuta [cd]pentalen-1a(2H)-yloxy]-5,6-dihydroxy-4-methyl-2-oxabicyclo[2.2.1]hept-3-yl}methyl benzoate
I-2-Cyclohexene-1-carboxylic acid, 4,5-dihydroxy-, [(3S,5R,6S)-3-[(benzoyloxy)methyl]-3-[(1aR)-1H-3,4-dioxacyclobuta[cd ]pentalen-1a(2H)-yloxy]-5,6-dihydroxy-4-methyl-2-oxabicyclo[2.2.1]hept-1-yl]methyl ester
β-D-Glucopyranoside,(1aR,2S,3aR,5R,5aR,5bS) -5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4- i-dioxacyclobuta[cd]pentalen-1a(2H)-yl, 6-benzoate
{(1R,2S,3R,5R,6R,8S) -3-[(6-O-Benzoyl-β-D-glucopyranosyl)oxy]-6-hydroxy-8-methyl-9,10-dioxatetracyclo[4.3. 1.0.0]dec-2-yl}methyl benzoate
I-Jiangsu Yongjian Pharmaceutical Technology Co., Ltd
I-Jiangsu Yongjian Pharmaceutical Technology Co., Ltd., eyasungulwa ngoMashi 2012, iyibhizinisi lobuchwepheshe obuphezulu elihlanganisa i-R & D, ukukhiqiza nokudayisa.Isebenza kakhulu ekukhiqizeni, ukwenza ngokwezifiso kanye nenqubo yokukhiqiza ukuthuthukiswa kwezingxenye ezisebenzayo zemikhiqizo yemvelo, izinto zokubhekisela zemithi yendabuko yamaShayina kanye nokungcola kwezidakamizwa.Le nkampani itholakala e-China Pharmaceutical City, eDolobheni laseTaizhou, eSifundazweni saseJiangsu, okuhlanganisa nesizinda sokukhiqiza esingamamitha-skwele angu-5000 kanye nesisekelo se-R & D esingamamitha-skwele angu-2000.Isebenza ikakhulukazi izikhungo ezinkulu zocwaningo lwesayensi, amanyuvesi kanye namabhizinisi okukhiqiza izingcezu ze-decoction ezweni lonke.
Kuze kube manje, sesithuthukise izinhlobo ezingaphezu kuka-1500 zama-reagents emvelo, futhi saqhathanisa futhi salinganisa izinhlobo ezingaphezu kuka-300 zezinto zokubhekisela, ezingahlangabezana ngokugcwele nezidingo zokuhlolwa kwansuku zonke zezikhungo ezinkulu zocwaningo lwesayensi, ama-laboratories asenyuvesi kanye namabhizinisi okukhiqiza izingcezu ze-decoction.
Ngokusekelwe kumgomo wokholo oluhle, inkampani inethemba lokubambisana ngobuqotho namakhasimende ethu.Inhloso yethu wukusebenzela ukwenziwa kwesimanjemanje kwemithi yendabuko yamaShayina.
Ububanzi bebhizinisi obuzuzisayo benkampani
1.R & D kanye nokuthengiswa kwemithi yendabuko yamaShayina kanye nemikhiqizo yokulawula amakhemikhali;
2.Izinhlanganisela zomuthi wendabuko waseShayina ezenziwe ngokwezifiso ngokwezici zekhasimende
3.Ucwaningo ngezinga lekhwalithi kanye nokuthuthukiswa kwenqubo yokukhishwa kwemithi yendabuko yamaShayina (isitshalo).
4. Ukusebenzisana kwezobuchwepheshe, ukudluliswa kwezidakamizwa kanye nocwaningo nokuthuthukiswa kwezidakamizwa ezintsha.
Isevisi eyenziwe ngokwezifiso yezinto zokubhekisela zamakhemikhali zomuthi wendabuko waseShayina
I-Jiangsu Yongjian Pharmaceutical Technology Co., Ltd. ibambe iqhaza kakhulu ocwaningweni oluyisisekelo lwezinto ezisebenzayo zemithi yendabuko yamaShayina iminyaka engaphezu kweyishumi.Kuze kube manje, inkampani yenze ucwaningo olunzulu ngezinhlobo ezingaphezu kwe-100 zemithi yendabuko yaseShayina evame ukusetshenziswa, futhi yakhipha izinkulungwane zezingxenye zamakhemikhali.
Inkampani inabasebenzi abaphezulu be-R & D kanye nemishini yokuhlola nokuhlaziya ephelele embonini, futhi isize amakhulu ezikhungo zocwaningo lwesayensi.Ingakwazi ukuhlangabezana nezidingo zamakhasimende ngokushesha nangempumelelo.
Ukuhlukaniswa Kokungcola Kwezidakamizwa, Ukulungiselela kanye Nesevisi Yokuqinisekisa Isakhiwo
Ukungcola kwezidakamizwa kuhlobene kakhulu nekhwalithi, ukuphepha kanye nokuzinza kwezidakamizwa.Ukulungiswa nokuqinisekiswa kwesakhiwo sokungcola emithini kungasisiza siqonde izindlela zokungcola futhi kunikeze isisekelo sokuthuthukisa inqubo yokukhiqiza.Ngakho-ke, ukulungiswa nokuhlukaniswa kokungcola kubaluleke kakhulu ocwaningweni nasekuthuthukisweni kwezidakamizwa.
Kodwa-ke, okuqukethwe kokungcola emthini kuphansi, umthombo ubanzi, futhi isakhiwo sifana kakhulu nengxenye eyinhloko.Yibuphi ubuchwepheshe obungasetshenziswa ukuhlukanisa nokuhlanza konke ukungcola emthini ngamunye ngamunye futhi ngokushesha?Yiziphi izindlela nezindlela ezisetshenziswayo ukuze kuqinisekiswe ukwakheka kwalokhu kungcola?Lobu ubunzima kanye nenselelo ebhekene namayunithi amaningi emithi, ikakhulukazi amabhizinisi emithi yezitshalo kanye nemithi yobunikazi yamaShayina.
Ngokusekelwe ezidingweni ezinjalo, inkampani yethule izinsiza zokuhlukanisa ukungcola kwezidakamizwa kanye nezinsizakalo zokuhlanza.Ngokuthembela ku-nuclear magnetic resonance, i-mass spectrometry nezinye izinto zokusebenza nobuchwepheshe, inkampani ingakwazi ukubona ngokushesha ukwakheka kwezinhlanganisela ezihlukanisiwe, ukuze ihlangabezane nezidingo zamakhasimende.
I-SPF Animal Experiment
Indawo yokwakhiwa kwendawo yokuhlolwa kwezilwane ingamamitha-skwele ayi-1500, okuhlanganisa namamitha-skwele angama-400 wendawo yokuhlola yezinga le-SPF kanye namamitha-skwele ayi-100 welebhu yeseli yezinga le-P2.Iholwa ososayensi base-China Pharmaceutical University, yakha ithimba lezobuchwepheshe elibalulekile elinenani labantu ababuyayo.Nikeza amamodeli ezilwane ekhwalithi ephezulu, idizayini yokuhlola, amaphrojekthi aphelele kanye nezinye izinsizakalo zocwaningo lwesayensi ye-biomedical, ukufundisa nokuthuthukiswa kwezimboni.
Ububanzi Bebhizinisi:
1. Ukuphakelwa kwezilwane ezincane
2. Ukumodela izifo zezilwane
3. Ukunikezwa kwephrojekthi yasekolishi
4. Ukuhlolwa kwe-Pharmacodynamic ku-vivo
5. Ukuhlolwa kwe-Pharmacokinetic
6. Isevisi yokuhlola iseli yesimila
Amandla ethu:
1. Gxila ekuhloleni kwangempela
2. Qinisekisa ngokuqinile inqubo
3. Sayina ngokuqinile isivumelwano sobumfihlo
4. Ilabhorethri Yakho ngaphandle kwezixhumanisi eziphakathi nendawo
5. Ithimba lochwepheshe bezobuchwepheshe liqinisekisa ikhwalithi yokuhlola
Indawo yokuhlola ye-SPF, ukuphakelwa komuntu okwabelwe ngokukhethekile, inqubekelaphambili yokuhlola yokulandelela ngesikhathi sangempela
