I-Cycloastragenol CAS No. 78574-94-4
Ukucaciswa Komkhiqizo
[igama]:i-cycloastragalus utshwala
[isibizo]:i-triterpenoid cyclic flavonol
[Igama lesiNgisi]:i-cycloastragenol
[ifomula yamangqamuzana]:I-C30H50O5
[isisindo samangqamuzana]:490.71
[Inombolo ye-CAS]:78574-94-4
[indlela yokuthola]:I-HPLC ≥ 98%
[Ukucaciswa]:20mg 50mg 100mg 500mg 1g (ingahlanganiswa ngokuvumelana nezidingo zekhasimende)
[izakhiwo]:lo mkhiqizo uyi-acicular crystal engenambala
[ukusebenza nokusetshenziswa]:Lo mkhiqizo usetshenziselwa ukunquma okuqukethwe, ukuhlonza, ukuhlola kwemithi, ukuhlola umsebenzi nokunye ukuhlola kocwaningo lwesayensi.Okufana nokuphathwa kwamaseli, ukuhlolwa kwe-intragastric, ukuhlolwa kwekhwalithi yangaphakathi yefekthri yezemithi, njll.Umthombo: Astragalus membranaceus (Fisch.) Bge.Ukukhishwa kwezimpande ezomile
Indlela Yesitoreji
I-2-8 ° C, ivalwe ekukhanyeni futhi igcinwe ekushiseni okuphansi.
Qaphela
Lo mkhiqizo kufanele ugcinwe ekushiseni okuphansi.Uma ivezwa emoyeni isikhathi eside, okuqukethwe kuzoncishiswa.
Izimo zeChromatographic} ikholomu yechromatographic: Zorbax rx-c18 (4.6mm) × 150mm)，5 μ m; Isigaba seselula: amanzi e-acetonitrile (30:70);Izinga lokugeleza: 1.0ml/min, izinga lokushisa lekholomu: 35 ℃, amapharamitha e-ELSD: izinga lokushisa leshubhu le-drift: 105 ℃, izinga lokugeleza kwe-nitrogen: 2.70ml/min.
Izakhiwo ze-Physicochemical: Ukuminyana 1.20
I-Bioactivity ye-cycloastragenol
I-Cycloastragalol iyinhlanganisela ye-triterpene saponin, eyi-Astragalus membranaceus (Fisch.) I-hydrolyzate yesithako esisebenzayo ku-Bunge).I-Astramembrangenin inokuphepha komlomo futhi inohlu olubanzi lwemiphumela yezemithi, okuhlanganisa ukusebenza kwe-telomerase, ukunwetshwa kwe-telomere, izakhiwo zokulwa nokuvuvukala kanye ne-antioxidant.I-Astramembrangenin inezindawo zokulwa nokuguga.I-CAG ivuselela umsebenzi we-telomerase kuma-keratinocyte abantu abasanda kuzalwa namaseli ezinzwa zamagundane futhi yenza kusebenze i-CREB.I-Astramembrangenin ingase ibe nomphumela omusha wokwelapha ekucindezelekeni
Izigaba ezifanele:
Indlela yokusayina > > i-apoptosis > > i-apoptosis
Inkambu yocwaningo > > ukuvuvukala / ukungatheleleki
Inkundla yocwaningo > > izifo zemizwa
Isifundo se-In Vitro:
Uma kuqhathaniswa nokulawulwa kwenethiwekhi kusiko lwe-HEK, iphrotheni ye-membrane yenkanyezi (0-10 μ M; izinsuku ezingu-3-6) yandisa ukukhula kwamaseli [1].I-Astramembrangenin (0.3 μ M;5-90 imizuzu) yenze i-CREB phosphorylation kuma-neuron ayinhloko e-cortical, futhi ukuvezwa kwe-CREB ephelele kuzo zombili izinhlobo zamaseli akuthintwanga yi-CAG [1].Iphrotheni ye-membrane yenkanyezi (3) μ M;Amahora we-6-48) angakhuthaza ukuguqulwa kwesignali ye-vivo kuma-neurons, akhulise inkulumo ye-TERT mRNA, futhi abonise ukukhushulwa kwe-bcl 2 mRNA inkulumo [1].Ukuhlolwa kokusebenza kweseli [1] umugqa weseli: I-HEK cell concentration: 1 μ M, 3 μ M, 10 μ M isikhathi sesiko: Imiphumela yezinsuku ezingu-3-6: ukukhula kweseli kuphindwe kabili ezinsukwini ezingu-6.Ukuhlaziywa kwe-blot yaseNtshonalanga [1] umugqa weseli: ukugxila kwamaseli e-neuron: 0.3 μ M isikhathi sesiko: imizuzu emi-5, imizuzu eyi-15, imizuzu engama-30, imizuzu engama-90.Imiphumela: I-CAG yenza kusebenze i-CREB kuma-neurons.I-RT-PCR [1] i-cell line: i-neuron cell concentration: 3 μ M isikhathi sesiko: imiphumela yamahora angu-6-48: ukuvezwa kwe-TERT ne-Bcl 2 mRNA kwanda.
Ireferensi:
[1].Ip FC, et al.I-Cycloastragenol iyi-activator ye-telomerase enamandla kumaseli e-neuronal: imiphumela yokulawulwa kokucindezeleka.Ama-Neurosignals.2014;22(1):52-63.
[2].U-Yu Y, nabanye.I-Cycloastragenol: Ikhandidethi yenoveli ethokozisayo yezifo ezihlobene nobudala.Exp Ther Med.2018 Sep;16(3):2175-2182.
[3].Sun C, et al.I-Cycloastragenol yenza kusebenze kanye nokucindezelwa kokwanda kwe-concanavalin A-induced mouse lymphocyte pan-activation model.Immunopharmacol Immunotoxicol.2017 Jun;39(3):131-139.
Izakhiwo zePhysicochemical Of Cycloastragenol
Ukuminyana:1.2 ± 0.1 g / cm3
Indawo yokubilisa:617.2 ± 55.0 ° C ku-760 mmHg
Iphoyinti lokuncibilika:241.0 kuya ku-245.0 ° C
Ifomula ye-molecular:c30h50o5
Isisindo samangqamuzana:490.715
Iphoyinti le-Flash:327.1 ± 31.5 ° C
Isisindo esiqondile:490.365814
I-PSA:90.15000
I-LogP:3.82
I-Steam Pressure:0.0 ± 4.0 mmHg ku-25 ° C
Inkomba ye-refractive:1.582
Ulwazi Lokuphepha lwe-Cycloastragenol
Ikhodi yokuthutha yezimpahla eziyingozi: i-nonh yazo zonke izindlela zokuthutha
inombolo ye-RTECS;I-GX8265000
Ikhodi Yempahla: 2942000000
Cycloastragalol Customs
Ikhodi Yempahla: 2942000000
Cycloastragalol Literature
I-Cycloastragenol iyi-activator ye-telomerase enamandla kumaseli e-neuronal: imiphumela yokulawulwa kokucindezeleka.
I-Neurosignals 22(1) , 52-63, (2014)
I-Cycloastragenol (CAG) iyi-aglycone ye-astragaloside IV.Yaqala ukuhlonzwa lapho kuhlolwa izingcaphuno ze-Astragalus membranaceus zezithako ezisebenzayo ezinezakhiwo zokulwa nokuguga.Ucwaningo lwamanje lwe...
I-activator ye-telomerase inoveli icindezela ukulimala kwamaphaphu kumodeli ye-murine ye-idiopathic pulmonary fibrosis.
I-PLoS ONE 8(3) , e58423, (2013)
Ukuvela kwezifo ezihlobene nokungasebenzi kahle kwe-telomere, okuhlanganisa ingculaza, i-aplastic anemia kanye ne-pulmonary fibrosis, kuye kwaqinisa isithakazelo kuma-activators e-telomerase.Sibika ngokuhlonzwa kwe-n...
Ukuthuthukiswa kwe-pharmacologic okusekelwe ku-telomerase komsebenzi we-antiviral we-CD8+ T lymphocyte yabantu.
J. Immunol.181(10), 7400-6, (2008)
I-telomerase reverse ibhala i-telomere DNA emaphethelweni ama-chromosome aqondile futhi ibambezela ukuguga kwamaselula.Ngokuphambene namaseli amaningi avamile e-somatic, abonisa umsebenzi omncane noma awekho nhlobo we-telomerase, i-immun...
Isibizo sesiNgisi seCycloastragalol
9,19-Cyclolanostane-3,6,16,25-tetrol,20,24-epoxy-,(3β,6α,9β,16β,20R,24S)-
I-Astramembrangenin
(3β,6α,9β,16β,20R,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol
19-Cyclolanostane-3,6,16,25-tetrol,20,24-epoxy-,(3β,6α,9β,16β,20R,24R)-
(3β,6α,9β,16β,20R,24S)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol
Cyclosieversigenin
Cyclogalegegenin
