Danshensu
Ukucaciswa Komkhiqizo
Igama elijwayelekile:Danshensu
Inombolo ye-CAS:76822-21-4
Ukuminyana:1.5 ± 0.1 g / cm3
I-Molecular Formula:I-C9H10O5
I-MSDS:n / indawo ekhanyayo: 259.1 ± 23.8 ° C
Igama lesiNgisi:Danshensu
Isisindo se-Molecular:198.17
Indawo yokubilisa:198.17
I-Melting Point:N/ A
Igama le-Danshensu
Igama lesiShayina:Danshensu
Igama lesiNgisi:(2R) - 3 - (3,4-dihydroxyphenyl) - 2-hydroxypropanoic acid
Isiteketiso sesiShayina:B - (3,4-dihydroxyphenyl) i-lactic acid |cryptotanshinone |B - (3.4-dihydroxyphenyl) i-lactic acid
I-Danshensu bioactivity
Incazelo:I-Danshensu iyingxenye esebenzayo ye-Salvia miltiorrhiza, engenza kusebenze indlela yokubonisa i-Nrf2 futhi ivikele uhlelo lwenhliziyo nemithambo yegazi.
Izigaba Ezihlobene: indlela yokusayina > > autophagy > > autophagy
Indlela yesiginali > > NF- κ B indlela yesiginali > > keap1-nrf2
Umkhakha wocwaningo > > isifo senhliziyo
Imikhiqizo yemvelo > > ama-benzoic acid
Isifundo se-In Vitro:I-Danshensu (DSS) inciphise kakhulu amazinga e-marker enzymes (i-creatine kinase ne-lactate dehydrogenase) ye-coronary outflow kanye nosayizi we-myocardial infarction.Lokhu kungase kukhuthaze kakhulu ukululama kokusebenza kwenhliziyo ngemva kokulimala kwe-I/R.I-DSS iphinde ibe nomsebenzi wokuxosha we-ROS futhi ikhuthaze umsebenzi wama-antioxidants angapheli afana ne-SOD, ikati, i-MDA, i-GSH-Px ne-HO-1 ngokwenza kusebenze indlela yokusayina ye-nuclear factor erythrocyte-2 factor 2 (Nrf2) elamula i-Akt ne-ERK1.2 ekuhlaziyweni kwe-blot yaseNtshonalanga [2].
Esifundweni Se-Vivo:Ukwelashwa okunamandla ngomthamo owodwa we-Danshensu akuzange kushintshe i-plasma tHcy kumagundane ane-tHcy evamile.Ngokuphambene, i-Danshensu yehlise kakhulu i-tHcy kumagundane ane-tHcy ephakeme.Amazinga aphezulu e-cysteine ne-glutathione ngemva kokwelashwa nge-Danshensu abonisa ukuthi umphumela wawo wokunciphisa i-tHcy ungokwandisa umsebenzi we-trans vulcanization pathway [1].
Ukuhlolwa kwezilwane:wonke amakhemikhali ahlakazwa ku-saline ngaphandle kwe-tolcapone encibilikisiwe ku-saline equkethe i-20% (V / V) isikhonkwane se-200. Ngesikhathi sokuhlolwa, amagundane azila ukudla ubusuku bonke futhi abelwe amaqembu ahlukene ngokungahleliwe.Ngemuva kwe-ether anesthesia, cishe i-200 yakhishwa egazini le-orbital sinus μ L, yabe isibulala amagciwane ngokushesha ngotshwala bese ucindezela ukotini.Amasampula egazi aqoqwa ngokushesha kumashubhu e-polypropylene aqukethe i-heparin sodium kanye ne-centrifuged ku-5000 g ku-5 ° C imizuzu engu-3.Amasampula e-plasma alungisiwe agcinwa ku-20 ℃ futhi ahlaziywa phakathi namahora angama-48.
Izithenjwa:[1] YG Cao, et al.Imiphumela enenzuzo ye-danshensu, ingxenye esebenzayo ye-Salvia miltiorrhiza, ku-homocysteine metabolism nge-trans-sulphuration pathway kumagundane.Br J Pharmacol.2009 Jun;157(3): 482–490.
[2].Yu J, et al.I-Danshensu ivikela inhliziyo eyedwa ekulimaleni kwe-ischemia kabusha ngokusebenza kokusayina kwe-Akt/ERK1/2/Nrf2.I-Int J Clin Exp Med.2015 Sep 15;8(9):14793-804.
Izakhiwo ze-Physicochemical of Danshensu
Ukuminyana:1.5 ± 0.1 g / cm3
I-Molecular Formula:I-C9H10O5
I-Flash Point:259.1 ± 23.8 ° C
I-LogP:- 0.29
I-Refractive Index:1.659
Indawo yokubilisa:481.5 ± 40.0 ° C ku-760 mmHg
Isisindo se-Molecular:198.17
I-PSA:97.99000
I-Steam Pressure:0.0 ± 1.3 mmHg ku-25 ° C
Ulwazi Lokuphepha lwaseDanshensu
Ikhodi Yempahla: 2942000000
Isibizo sesiNgisi saseDanshensu
Danshensu
I-Sodium (2R) -3-(3,4-dihydroxyphenyl) -2-hydroxypropanoate
(2R)-3-(3,4-Dihydroxyphenyl) -2-hydroxypropanoic acid
I-Benzenepropanoic acid, α, 3,4-trihydroxy-, (αR) -
I-Benzenepropanoic acid, α,3,4-trihydroxy-, usawoti wesodium, (αR)- (1:1)
I-Salvianic
