I-Fraxin;Paviin;I-Fraxoside;I-Fraxetol- 8-glucoside CAS No.524-30-1
Ulwazi Olubalulekile
Inombolo ye-CAS:524-30-1 [1]
Inombolo ye-EINECS:208-355-5
I-Molecular Formula:c16h18o10
Isisindo se-Molecular:370.3081
Isakhiwo samangqamuzana:(Umfanekiso 1)
Izakhiwo:I-crystal acicular ekhanyayo ephuzi noma i-flake crystal.
Ukuminyana:1.634g/cm3
Indawo yokubilisa:722.2 ° C ku-760 mmHg
I-Flash Point:267 ° C
I-Steam Pressure:6.87e-22mmhg ku-25 ° C
I-Bioactivity ye-Fraxin
Incazelo:I-Fraxin ingahlukaniswa ne-Acer tegmentosum, F. ornus kanye ne-a.i-hippocastanum.Kuyi-glycoside ye-fraxine [1] futhi ine-antioxidant, anti-inflammatory kanye nemisebenzi ye-anti metastasis.I-Fraxin ibonisa umsebenzi we-antioxidant ngokuvimbela i-cyclic adenylate phosphodiesterase [2].
Ithagethi:i-cyclo AMP phosphodiesterase enzyme [2]
Isifundo se-In Vitro:I-Fraxin (100 μ M) Ayinayo i-cytotoxicity kumaseli e-Hep G2.I-Fraxin ekugxilweni okungeyona i-cytotoxic yehlise kakhulu ukukhiqizwa kwe-ROS kwe-t-BHP ngendlela encike kumthamo [1].I-Fraxin (0.5 mm) ingasusa ama-radicals mahhala ekugxiliseni okuphezulu futhi inomphumela we-cytoprotective ku-H2O2 ye-oxidative oxidative stress [2].
Ucwaningo lwe-vivo:I-Fraxin (50 mg / kg, PO) ivimbe ngokuphawulekayo ukuphakama okudalwe yi-CCl4 kwe-ALT ne-AST.I-Fraxin (i-10 kanye ne-50 mg / kg, i-PO) inciphise kakhulu amazinga e-GSSG (1.7 ± 0.3 kanye ne-1.5 ± 0.2 nm / g yesibindi, ngokulandelana) uma kuqhathaniswa namazinga e-GSSG eqenjini eliphathwayo le-CCl4
Ireferensi:.I-Fraxin (50 mg/kg, po) ivimba ngokuphawulekayo ukuphakama okubangelwa i-CCl4 kwe-ALT ne-AST.I-Fraxin (10 kanye ne-50 mg/kg, po) inciphisa ngokuphawulekayo amazinga e-GSSG (1.7±0.3 kanye ne-1.5±0.2 nM/g yesibindi, ngokulandelana) uma kuqhathaniswa namazinga e-GSSG eqembu eliphathwe i-CCl4[1].
[2].Whang WK, et al.Izinhlanganisela zemvelo, i-fraxin namakhemikhali ahlobene ne-fraxin avikela amaseli ekucindezelekeni kwe-oxidative.Exp Mol Med.2005 Okthoba 31;37(5):436-46.
