Imikhiqizo

Incazelo:I-glucoridin iyi-isoflavane evela ku-glycorrhiza glabra, engabopha futhi yenze i-PPAR γ isebenze, Inani le-EC50 ngu-6115 nm.I-Glabridin ine-antioxidant, i-antibacterial, i-anti glomerulonephritis, i-anti-diabetes, i-anti-tumor, i-anti-inflammatory, i-anti-osteoporosis, ivikela inhliziyo nemithambo yegazi, ivikele izinzwa, ikhiphe ama-radicals mahhala neminye imisebenzi.

Izigaba Ezihlobene:umkhakha wocwaningo > > umdlavuza
Umzila wamasignali > > umjikelezo weseli / ukulimala kweDNA > > PPAR
Inkambu yocwaningo > > ukuvuvukala / ukungatheleleki

Isifundo se-In Vitro:i-glabridin ibopha futhi isebenze i-PPAR γ, i-EC50 ingu-6115 nm [1].I-Glabridin (40,80 μ M) Ukusabalala kwemigqa yeseli ye-SCC-9 kanye ne-SAS kwakuvinjelwe ngomthamo nangendlela encike esikhathini ngemva kwamahora angu-24 nama-48 okwelashwa [2].I-Glabridin (0-80 μ M) Iphinde ifake i-apoptosis, okuholela ekuboshweni komjikelezo weseli ye-G1 ku-SCC-9 kanye nemigqa yeseli ye-SAS [2].I-Glabridin (0,20,40 kanye no-80 μ M) Idosi isebenze ngokuncika i-Caspase-3, - 8 kanye - 9 futhi yanda i-PARP cleavage, ngokuphawulekayo phosphorylating ERK1 / 2, JNK1 / 2 kanye ne-P-38 MAPK ku-SCC-9.Amaseli [2].

Esifundweni Se-Vivo:I-glabridin (50 mg / kg, Po kanye ngosuku) ibonise umsebenzi onamandla wokulwa nokuvuvukala futhi yathuthukisa izinguquko zokuvuvukala ezibangelwa i-dextran sodium sulfate (DSS) [3]

Izithenjwa:[1] URebhun JF, et al.Ukuhlonzwa kwe-glabridin njengenhlanganisela ye-bioactive ku-licorice (i-Glycyrrhiza glabra L.) ekhipha eyenza i-peroxisome proliferator-activated receptor gamma isebenze (PPAR γ).I-Fitoterapia.2015 Okthoba;106:55-61.
[2].U-Chen CT, et al.I-Glabridin yenza i-apoptosis kanye nokuboshwa komjikelezo weseli kumaseli omdlavuza womlomo ngokusebenzisa indlela yokubonisa i-JNK1/2.I-Environ Toxicol.2018 Jun;33(6):679-685.
[3].El-Ashmawy NE, et al.Ukwehliswa kwe-iNOS kanye nokuphakama kwe-cAMP kulamula umphumela wokulwa nokuvuvukala kwe-glabridin kumagundane ane-ulcerative colitis.I-Inflammopharmacology.2018 Ephreli;26(2):551-559.