Hyperoside;Hypercin Cas No. 482-36-0
Ulwazi Lwezidakamizwa
[igama lomkhiqizo] i-hypericin
[Igama lesiNgisi] Hyperoside
[igama elingaziwa] hyperin, quercetin 3-galactoside, quercetin-3-o-galactoside
[ifomula yamangqamuzana] c21h20o12
[isisindo samangqamuzana] 464.3763
[C njengeNo.] 482-36-0
[ukuhlukaniswa kwamakhemikhali] ama-flavonoid
[umthombo] Hypericum perforatum L
[Ukucaciswa] > 98%
[Amagama okuphepha] 1. Ungaphefumuli uthuli.2.Uma kwenzeka ingozi noma ungaphathekile kahle, funa usizo lwezempilo ngokushesha (bonisa ilebula layo uma kungenzeka).
[Ukusebenza kwe-Pharmacological] I-Hypericin isatshalaliswa kabanzi.Kungumkhiqizo wemvelo obalulekile onemisebenzi ehlukahlukene yomzimba, njengokulwa nokuvuvukala, i-antispasmodic, i-diuretic, ukukhwehlela, ukunciphisa umfutho wegazi, ukwehlisa i-cholesterol, ukutholwa kwamaprotheni, i-analgesia yendawo kanye nemaphakathi, kanye nemiphumela yokuvikela emithanjeni yenhliziyo neyobuchopho.
[Izici ezibonakalayo namakhemikhali] Ikristalu e-acicular ephuzi ephuzi.Iphuzu elincibilikayo lingu-227 ~ 229 ℃, futhi ukujikeleza kwe-optical kungu-83 ° (C = 0.2, pyridine).Incibilika kalula ku-ethanol, i-methanol, i-acetone ne-pyridine futhi izinzile ngaphansi kwezimo ezivamile.Isabela nge-hydrochloric acid magnesium powder ukukhiqiza okubomvu kwe-cherry, futhi i-ferric chloride iphendula ngokuluhlaza, ukusabela kwe-α-Naphthol kwaba kuhle.
[Igama lengozi] Iyingozi uma igwinywe.
Isenzo se-Pharmacological
1. I-Hypericin inomphumela obalulekile wendawo we-analgesic, obuthaka kune-morphine, unamandla kune-aspirin, futhi ayinakho ukuncika.I-Hypericin uhlobo olusha lwe-analgesic yendawo Ngasikhathi sinye,
2. I-Hypericin inomphumela omuhle wokuvikela ku-myocardial ischemia-reperfusion, i-cerebral ischemia-reperfusion kanye ne-cerebral infarction.
3. I-Hypericin inomphumela ocacile wokulwa nokuvuvukala: ngemva kokufakwa kwebhola loboya, amagundane ajovwe nge-intraperitoneally nge-20mg / kg nsuku zonke izinsuku ezingu-7, okwavimbela kakhulu inqubo yokuvuvukala.
4. Inomphumela onamandla we-antitussive.
5. Ukufanisa.
6. Ukuvinjelwa okuqinile kwe-aldose reductase kungase kube yinzuzo ukuvimbela i-cataract yesifo sikashukela.
Umphumela wokuvikela ku-ischemia ye-myocardial
I-Hypericin inganciphisa izinga le-apoptosis ye-cardiomyocyte ebangelwa i-hypoxia reoxygenation, ivimbele ukukhululwa kwe-lactate dehydrogenase, ithuthukise umsebenzi we-myocardial superoxide dismutase (SOD) kumagundane anokulimala kwe-myocardial ischemia-reperfusion, ukunciphisa ukukhiqizwa kwe-malondialdehyde (MDA), vimbela ukwanda kwe-myocardial phosphokinase (CPK) ku-serum, futhi kunciphise ukwakheka kwe-oxygen free radical and nitric oxide free radical, Ukuze kuvikelwe i-myocardium nokunciphisa ukulimala kwe-cardiomyocyte kanye ne-cardiomyocyte apoptosis ebangelwa i-ischemia-reperfusion.
Umphumela wokuvikela ku-ischemia ye-cerebral
I-Hypericin inganqanda ngempumelelo ukwehla kokuqukethwe kwe-formazan ezincekwini zobuchopho ngemva kokulimala kabusha kwe-hypoxia glucose deprivation reperfusion, ikhulise inani lama-neurons asekhona ku-cortex kanye ne-striatum yezingcezu zobuchopho endaweni ye-ischemic, futhi yenze i-morphology yama-neurons iphelele futhi isabalaliswe kahle.Vimbela ukwehla komsebenzi we-neuronal obangelwa ukulimala kabusha kwe-hypoxia glucose deprivation reperfusion.Vimbela ukwehla kwemisebenzi ye-SOD, LDH kanye ne-glutathione peroxidase (GSHPx).Indlela yayo ingase ihlobane nokukhishwa kwe-radical yamahhala, ukuvimbela ukungena kwe-Ca2 kanye nokwakheka kwe-anti lipid peroxide.
Umthelela wokuvikela esibindini kanye ne-gastric mucosa
I-Hypericin inomphumela osobala wokuvikela kuzicubu zesibindi kanye ne-gastric mucosa.Indlela yayo ihlobene nomphumela we-antioxidant, okhuthaza ukubuya kwezinga le-N0 kumsebenzi ojwayelekile nokwandisa umsebenzi we-SOD.
Umphumela we-antispasmodic we-analgesic
Ucwaningo lwathola ukuthi umphumela we-analgesic we-hypericin ukhiqizwa ngokunciphisa i-Ca 2 emiphethweni yemizwa ebuhlungu.Ngesikhathi esifanayo, i-hypericin ingavimbela ukungena kwe-Ca 2 okubangelwa i-potassium ephezulu, okubonisa ukuthi i-hypericin iphinde ivimbele isiteshi se-Ca esicutshini sezinzwa.Kuphinde kuphakanyiswe ukuthi i-hypericin ingaba i-blocker ye-Ca 2 channel.Ukubhekwa komtholampilo kubonisa ukuthi umjovo we-hypericin ufana ne-atropine ekwelapheni i-dysmenorrhea eyinhloko.Ngaphandle kwemiphumela ethile engathandeki yokozela, ayinakho ukusabela okubi okujwayelekile okufana ne-tachycardia, i-mydriasis kanye nomuzwa ovuthayo.Kuyi-antispasmodic ekahle kanye ne-analgesic.
Umphumela we-Hypolipidemic
I-Hypericin inganciphisa kakhulu i-serum TC futhi ikhulise isilinganiso se-HDL/TC kumagundane anamafutha amaningi, okubonisa ukuthi i-hypericin inganciphisa i-cholesterol, ilawule i-lipid yegazi, futhi ithuthukise umsebenzi we-HDL ne-serum SOD kumagundane.Lo mphumela unganciphisa kakhulu umonakalo we-superoxide free radical to vascular endothelium ku-hyperlipidemia, futhi uvumela ukubola kanye ne-metabolism ye-lipid peroxide ukuvikela i-vascular endothelium.
Thuthukisa ukusebenza kokuzivikela komzimba
I-Hypericin ngemithamo engu-300 mg/kg no-150 mg/kg ku-vivo ingavimbela ngokuphawulekayo inkomba ye-thymus, ukwanda kwama-lymphocyte T no-B we-spleen kanye ne-phagocytosis yama-macrophages e-peritoneal;Ku-59 mg / kg, kuthuthukise kakhulu ukwanda kwe-spleen T no-B lymphocyte kanye ne-phagocytosis yama-macrophages e-peritoneal.I-Hypericin kumthamo we-50 ~ 6.25 ml ku-vitro ingakhuthaza kakhulu ukwanda kwe-spleen T no-B lymphocyte futhi ithuthukise ikhono le-T lymphocyte ukukhiqiza i-IL-2;I-Hypericin ku-6.25 g / ml ikhulise kakhulu ikhono legundane le-peritoneal macrophages ukuze i-phagocytize neutrophils, kusukela ku-12.5 kuya ku-3.12 μ G / ml ikhulise kakhulu ikhono legundane le-peritoneal macrophages lokukhulula inombolo.
Umphumela we-antidepressant
Ukwenziwa kusebenze kwe-Hypothalamic pituitary adrenal (HPA) kuwushintsho oluvamile lwebhayoloji ezigulini ezinokucindezeleka okukhulu, olubonakala ngokuphuma ngokweqile kwehomoni ye-adrenocorticotropic (ACTH) ne-cortisol.I-Hypericin ingalawula ukusebenza kwe-axis ye-HPA futhi inciphise amazinga e-ACTH ne-corticosterone, ukuze idlale indima yokuvimbela ukucindezeleka.
Isidakamizwa esiphelile
Ciwujia capsule
I-Acanthopanax senticosus capsule iyilungiselelo elinesiqu se-Acanthopanax senticosus kanye ne-leaf extract njengento eluhlaza.Ingxenye eyinhloko i-flavonoids, lapho i-hypericin iyingxenye eyinhloko esebenzayo yamaqabunga e-Acanthopanax senticosus.
Izinkomba eziyinhloko: ukukhuthaza ukujikeleza kwegazi nokususa i-stasis yegazi.Isetshenziselwa i-arthralgia yesifuba kanye nesifo senhliziyo esibangelwa ukuqina kwegazi.Izimpawu zihlanganisa ubuhlungu besifuba, ukucinana kwesifuba, ukushaya kwenhliziyo, umfutho wegazi ophakeme, njll. kungenxa yokuntuleka kobende nezinso negazi kanye ne-Yin.
I-Xinan capsule
Kuyilungiselelo elenziwe nge-hawthorn leaf extract, elicebile ngama-flavonoids, lapho i-hypericin ingenye yezingxenye eziyinhloko.
Izinkomba eziyinhloko: ukwandisa uhlelo lwe-coronary cardiovascular, ngcono ukuhlinzekwa kwegazi le-myocardial futhi unciphise i-lipid yegazi.Isetshenziselwa ukwelapha isifo senhliziyo, i-angina pectoris, ukuqina kwesifuba, ukushaya kwenhliziyo, umfutho wegazi ophakeme, njll.
Ithebhulethi ye-Qiyue Jiangzhi
Ithebhulethi ye-Qiyue Jiangzhi umuthi wendabuko wamaShayina ohlanzekile owehlisa i-lipid olungiselelwe ngokukhipha izingxenye ezisebenzayo zokwelapha zesiShayina ezifana ne-hawthorn (enucleated) ne-Astragalus membranaceus.Enye yezingxenye eziyinhloko ezisebenzayo ze-hawthorn yi-flavonoids, lapho okuqukethwe kwe-hypericin kuphezulu.
Izinkomba eziyinhloko: nciphisa i-lipid yegazi futhi uthambise imithambo yegazi.Isetshenziselwa ukuthuthukisa ukujikeleza kwegazi kwe-coronary kanye nokulwa ne-arrhythmia ne-hyperlipidemia.
Ithebhulethi ye-Xinxuening
Ithebhulethi ye-Xinxuening iyilungiselelo eliyinhlanganisela elenziwe ngomuthi wendabuko waseShayina njenge-hawthorn ne-pueraria.I-Hawthorn umuthi osemthethweni wephathi yethu.Iqukethe i-ursolic acid, i-Vitexin rhamnoside, i-hypericin, i-citric acid, njll, okuyi-hypericin eyingxenye eyinhloko.
Izinkomba eziyinhloko: ukukhuthaza ukujikeleza kwegazi nokususa i-stasis yegazi, ukugoqa izibambiso kanye nokukhulula ubuhlungu.Isetshenziselwa isifuba i-arthralgia kanye ne-vertigo ebangelwa ukusimama kwegazi kwenhliziyo kanye nokuqina kobuchopho, kanye nesifo senhliziyo, umfutho wegazi ophezulu, i-angina pectoris kanye ne-hyperlipidemia.
I-Yukexin capsule
I-Yukexin capsule iwukulungiswa komuthi wendabuko waseShayina owenziwe ngencwadi kadokotela yasendulo, eyakhiwe ngeHypericum perforatum, i-wild jujube kernel, igxolo le-Albizzia, i-Gladiolus neminye imithi yendabuko yamaShayina.Ngokuyinhloko iqukethe i-hypericin, i-quercetin, i-quercetin, i-chlorogenic acid, i-caffeic acid, i-yimaning, i-hypericin nezinye izingxenye.
Izinkomba eziyinhloko: ukucindezeleka kwengqondo okubangelwa ukungahlaliseki kwesibindi qi kanye nesimo sengqondo esibi.
