Isomucronulatol;7,2′ -Dihydroxy-3′, 4′ -dimethoxyisoflavan
Inhloso
I-Isomucronulatol iyi-flavonoid ehlukanisiwe nempande ye-A. membranaceus.I-Isomucronulatol ingavimbela i-IL-12 P40 ekhuthazwa yi-LPS ku-vitro futhi inomsebenzi ongase ube namandla wokulwa nokuvuvukala.
Umsebenzi Webhayoloji
Incazelo:I-isomucronulatol iyi-flavonoid ehlukanisiwe nempande ye-A. membranaceus.I-Isomucronulatol ingavimbela i-IL-12 P40 ekhuthazwa yi-LPS ku-vitro futhi inomsebenzi ongase ube namandla wokulwa nokuvuvukala.
Izigaba Ezihlobene:indlela yesignali > > enye > > enye
Inkambu yocwaningo > > ukuvuvukala / ukungatheleleki
Ireferensi:[1].Li W, et al.Ama-Flavonoids avela ku-Astragalus membranaceus kanye nokuvimbela kwawoimiphumela ekukhiqizweni kwe-pro-inflammatory cytokine ye-LPS kumaseli e-dendritic atholakala ngomnkantsha.I-Arch Pharm Res.2014 Feb;37(2):186-92.
Izakhiwo ze-Physicochemical
Ukuminyana: 1.3 ± 0.1 g / cm3
Indawo yokubilisa: 426.8 ± 45.0 ° C ku-760 mmHg
Ifomula yemolekyuli: c17h18o5
Isisindo se-molecule: 302.322
Iphoyinti elikhanyayo: 211.9 ± 28.7 ° C
Isisindo esinembile: 302.115417
I-PSA: 68.15000
I-logP:2.63
Umfutho we-steam: 0.0 ± 1.1 mmHg ku-25 ° C
Inkomba ye-refractive: 1.607
Isibizo sesiNgisi
2H-1-Benzopyran-7-ol, 3,4-dihydro-3-(2-hydroxy-3,4-dimethoxyphenyl)-
7,2'-Dihydroxy-3',4'-dimethoxyisoflavan
3-(2-Hydroxy-3,4-dimethoxyphenyl)-7-chromanol
2H-1-Benzopyran-7-ol,3,4-dihydro-3-(2-hydroxy-3,4-dimethoxyphenyl)
Isevisi eyenziwe ngokwezifiso yezinto ezisetshenziswa ngamakhemikhali ze-Chinese Med-icine yendabuko
I-Jiangsu Yongjian Pharmaceutical Technology Co., Ltd. ibambe iqhaza kakhulu ocwaningweni oluyisisekelo lwezinto ezisebenzayo zemithi yendabuko yamaShayina iminyaka engaphezu kweyishumi.Kuze kube manje, inkampani yenze ucwaningo olunzulu ngezinhlobo ezingaphezu kwe-100 zemithi yendabuko yaseShayina evame ukusetshenziswa, futhi yakhipha izinkulungwane zezingxenye zamakhemikhali.
Inkampani inabasebenzi abaphezulu be-R & D kanye nemishini yokuhlola nokuhlaziya ephelele embonini, futhi isize amakhulu ezikhungo zocwaningo lwesayensi.Ingakwazi ukuhlangabezana nezidingo zamakhasimende ngokushesha nangempumelelo.
Ukuhlukaniswa kokungcola kwezidakamizwa, ukulungiswa kanye nenkonzo yokuqinisekisa isakhiwo
Ukungcola kwezidakamizwa kuhlobene kakhulu nekhwalithi, ukuphepha kanye nokuzinza kwezidakamizwa.Ukulungiswa nokuqinisekiswa kwesakhiwo sokungcola emithini kungasisiza siqonde izindlela zokungcola futhi kunikeze isisekelo sokuthuthukisa inqubo yokukhiqiza.Ngakho-ke, ukulungiswa nokuhlukaniswa kokungcola kubaluleke kakhulu ocwaningweni nasekuthuthukisweni kwezidakamizwa.
Kodwa-ke, okuqukethwe kokungcola emthini kuphansi, umthombo ubanzi, futhi isakhiwo sifana kakhulu nengxenye eyinhloko.Yibuphi ubuchwepheshe obungasetshenziswa ukuhlukanisa ngokushesha kanye nokuhlanza konke ukungcola emthini ngamunye ngamunye?Yiziphi izindlela nezindlela ezisetshenziswayo ukuze kuqinisekiswe ukwakheka kwalokhu kungcola?Lobu ubunzima kanye nenselelo ebhekene namayunithi amaningi emithi, ikakhulukazi amabhizinisi emithi yezitshalo kanye nemithi yobunikazi yamaShayina.
Ngokusekelwe ezidingweni ezinjalo, inkampani yethule izinsiza zokuhlukanisa ukungcola kwezidakamizwa kanye nezinsizakalo zokuhlanza.Ngokuthembela ku-nuclear magnetic resonance, i-mass spectrometry nezinye izinto zokusebenza nobuchwepheshe, inkampani ingakwazi ukuhlonza ngokushesha ukwakheka kwezinhlanganisela ezihlukanisiwe, ukuze ihlangabezane nezidingo zamakhasimende.
Ukuhlolwa kwezilwane ze-SPF
Indawo yokwakhiwa kwendawo yokuhlolwa kwezilwane ingamamitha-skwele ayi-1500, okuhlanganisa namamitha-skwele angama-400 wendawo yokuhlola yezinga le-SPF kanye namamitha-skwele ayi-100 welebhu yeseli yezinga le-P2.Iholwa ososayensi base-China Pharmaceutical University, yakha ithimba lezobuchwepheshe elibalulekile elinenani labantu ababuyayo.Nikeza amamodeli ezilwane ekhwalithi ephezulu, idizayini yokuhlola, amaphrojekthi ewonke kanye nezinye izinsizakalo zocwaningo lwesayensi ye-biomedical, ukufundisa nokuthuthukiswa kwezimboni.
