I-Jujuboside A CAS No. 55466-04-1
Ulwazi Olubalulekile
Isibizo sesiShayina:ijube kernel saponin A, jujube kernel saponin A;I-Jujube kernel saponin A (okujwayelekile)
Igama lesiNgisi:Jujuboside A
Umthombo wesitshalo:iphuma embewini ye-jujube yasendle, eyaziwa nangokuthi i-jujube kernel kanye ne-wild jujube core
Ifomula ye-molecular:I-C58H94O26
Isisindo samangqamuzana:1207.35
Inombolo ye-CAS.55466-04-1
I-Bioactivity ye-Jujuboside A
Ithagethi:I-GABA receptor, mTOR, PI3K, Akt [1] [2]
Isifundo se-in vitro:umthamo ophansi 41 μ Jujuboside A we-M (cishe u-0.05 g / L) wenza i-GABA (a) ama-receptors phakathi nokwelashwa kwamahora angu-24 no-72 α 1, α 5, β 2 subunit mRNA anda kakhulu.Umthamo ophezulu 82 μ M (cishe u-0.1 g / L) I-Jujuboside A inyuse kakhulu i-GABA (a) ama-receptors ku-24 h α 1, α 5 ama-subunit mRNA amazinga futhi yehla izinga le-β 2 subunit mRNA futhi yehla i-GABA (a) iyunithi ye-receptor α 1， Inkulumo ye-β 2 mRNA iphathwe ku-72 h [1].I-Jujuboside A pretreatment ingahlehlisa ukwehla kokusebenza kweseli futhi ifake kangcono ukulimala kweseli okudalwe yi-ISO kwe-H9c2.I-Jujuboside A ingasheshisa i-phosphorylation ye-PI3K, Akt ne-mTOR.I-Jujuboside A inganciphisa ngokuphawulekayo ingxenye yamaprotheni ahlobene ne-microtubule LC3-II / I kumaseli e-H9c2 [2]
Ucwaningo lwe-vivo:phakathi nosuku (9:00-15:00), ama-jujubosides andisa kakhulu ubuthongo obuphelele kanye nokunyakaza kwamehlo okusheshayo (REM), kodwa ayengenawo umthelela obalulekile ebuthongweni obungeyona i-REM (NREM).Ebusuku (21:00-3:00), ama-jujubosides andisa kakhulu ukulala okuphelele nokulala kwe-NREM, ikakhulukazi ukulala okuncane, kodwa ayengenawo umthelela obalulekile ekulaleni kwe-REM kanye nokulala kwegagasi okunensayo (SWS) [3].Ukwelashwa kwe-intraventricular nge-jjuboside a kwancishiswa kakhulu nge-Y-maze, ukugwema okusebenzayo kanye nezilinganiso ze-Morris water maze β 1-42 eyenzelwe ukufunda nokukhubazeka kwenkumbulo kumagundane.Umjovo we-Intracerebroventricular we-Jujuboside A unciphise i-hippocampal a β 1-42 amazinga avimbele ngokuphawulekayo imisebenzi ye-acetylcholinesterase (AChE) futhi cha, futhi wehlisa okuqukethwe okwenyuka kwe-malondialdehyde (MDA) ku-hippocampus kanye ne-cerebral cortex yamagundane ajovwe ku-lateral β1 ventricle [4].
Ukuhlolwa kweseli:ngemva kwezinsuku ezingu-7 zesiko ku-vitro, amangqamuzana ayevezwe ngokuqhubekayo amahora angu-24 noma amahora angu-72, futhi awazange avezwe endaweni equkethe i-Jujuboside A noma i-diazepam noma kokubili.I-Vector yengezwe eqenjini lokulawula;Iqembu le-Diazepam lengeze i-10 μ M diazepam;I-Jujuboside A82 μ M (cishe u-0.1g / L) kanye no-41 μ M (cishe u-0.05 g / L) yengezwe ku-jua-h (umthamo ophezulu i-Jujuboside A) namaqembu e-jua-l (umthamo ophansi we-Jujuboside A), ngokulandelanayo.Isamba se-RNA sahlukaniswa kumaseli ukuze kuhlaziywe okwengeziwe [1].
Ukuhlolwa kwezilwane:amagundane: i-a yajovwa nge-ICV β 1-42 edalwe ukukhubazeka kwengqondo kumagundane.Bese, amagundane ajovwa nge-Jujuboside A (0.02 kanye no-0.2 mg / kg) nge-intraventricular (ICV) izinsuku ezingu-5.I-Y maze, ukugwema okusebenzayo kanye nokuhlolwa kwe-Morris water maze kwenziwa kumagundane [1].
Isibizo sesiNgisi sika-Jujuboside A
I-α-L-arabinopyranoside, (3β,16β,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[O-β-D-glucopyranosyl-(1->6)-O-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3 )]-
(3β,16β,23R)-20-Hydroxy-16,23:16,30-diepoxydammar-24-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D -glucopyranosyl-(1->6)-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3)]-α -L-arabinopyranoside
jujuboside C
I-α-L-Arabinopyranoside, (3β,16β,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[O-β-D-glucopyranosyl-(1->6)-O-[β-D-xylopyranosyl-(1->2)]- β-D-glucopyranosyl-(1->3 )]-
JujubosideA
(3β,16β,23R)-20-Hydroxy-16,23:16,30-diepoxydammar-24-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D -glucopyranosyl-(1->6)-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3)]-α-L-arabinopyranoside
