I-Methylophiopogonanone A;Opogonanone A
Ukusetshenziswa kwe-Methylophiopogonanone A
I-Methylophiopogonanone A iyi-flavonoid ekhishwe ku-Ophiopogon japonicas, ene-antioxidant ne-anti-inflammatory effects.
Igama likaMethylophiopogonanone A
Igama lesiNgisi:
(3R)-3-(1,3-benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydrochromen-4-one
Isiteketiso sesiShayina:
Ophiopogon methyl flavanone a |methyl Ophiopogon dihydrohomoisoflavone a |methyl Ophiopogon flavanone a
Umsebenzi Webhayoloji We-Methylophiopogonanone A
Incazelo: I-methylophiopogonanone A iyi-flavonoid ekhishwe ku-Ophiopogon japonicas,
imiphumela ye-antioxidant kanye ne-anti-inflammatory.
Izigaba Ezihlobene: indlela yesiginali > > i-apoptosis > > i-apoptosis
inkundla yocwaningo > > ukuvuvukala / ukungatheleleki
Ucwaningo lwe-In Vitro: i-methyl aspartate a (mo-a; 10 μ Mo (L / L) yehle kakhulu i-apoptosis kanye nenkulumo ye-Caspase-3, yanda isilinganiso se-Bcl-2 / Bax futhi ayibuyiselanga ukukhiqizwa. I-Methylaspartate a (mo-a) ukwelashwa kwangaphambili
kuthuthukise kakhulu ukusebenza kwendlela ye-PI3K / Akt / eNOS kumaseli e-H9c2 ngaphansi kwe-H / R, kuyilapho umphumela wokuvikela we-mo-a ukhanseliwe phambi kwe-PI3K inhibitor wortmannin (100 nmol / L) [1].
Ku-Vivo Study: umphumela wokuvikela we-methylaspartate a (mo-a; 10mg / kg / D, PO) ekusebenzeni kwenhliziyo ngemuva kokulimala kwe-myocardial I / R [1].
Izikhombo: [1] He F, et al.I-Methylophiopogonanone A icindezela i-ischemia/i-reperfusion-induced myocardial apoptosis kumagundane ngokuvula indlela yokusayina ye-PI3K/Akt/eNOS.I-Acta Pharmacol Sin.2016 Jun;37(6):763-71.
Izakhiwo ze-Physicochemical Of Methylophiopogonanone A
Ukuminyana: 1.4 ± 0.1 g / cm3
Indawo yokubilisa: 580.1 ± 50.0 ° C ku-760 mmHg
I-Molecular Formula: c19h18o6
Isisindo se-Molecular: 342.343
I-Flash Point: 212.9 ± 23.6 ° C
IMisa eliqondile: 342.110352
I-PSA:85.22000
I-logP:5.16
I-Steam Pressure: 0.0 ± 1.7 mmHg ku-25 ° C
Inkomba ye-Refractive: 1.654
Igama LesiNgisi Le-Methylophiopogonanone A
(1,3-Benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydro-4H-chromen-4-one
4H-1-Benzopyran-4-one, 3-(1,3-benzodioxol-5-ylmethyl) -2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-
I-N1002
Methylophiopogonanone A
Isevisi ye-Yongjian
Isevisi Eyenziwe Ngezifiso Yezikhombo Zezinto Zemithi Yendabuko YamaShayina
I-Jiangsu Yongjian Pharmaceutical Technology Co., Ltd. ibambe iqhaza kakhulu ocwaningweni oluyisisekelo lwezinto ezisebenzayo zemithi yendabuko yamaShayina iminyaka engaphezu kweyishumi.Kuze kube manje, inkampani yenze ucwaningo olunzulu ngezinhlobo ezingaphezu kwe-100 zemithi yendabuko yaseShayina evame ukusetshenziswa, futhi yakhipha izinkulungwane zezingxenye zamakhemikhali.
Inkampani inabasebenzi abaphezulu be-R & D kanye nemishini yokuhlola nokuhlaziya ephelele embonini, futhi isize amakhulu ezikhungo zocwaningo lwesayensi.Ingakwazi ukuhlangabezana nezidingo zamakhasimende ngokushesha nangempumelelo
Ukwehlukaniswa Kokungcola Kwezidakamizwa, Isevisi Yokulungiselela kanye Nesakhiwo Sokuqinisekisa
Ukungcola kwezidakamizwa kuhlobene kakhulu nekhwalithi, ukuphepha kanye nokuzinza kwezidakamizwa.Ukulungiswa nokuqinisekiswa kwesakhiwo sokungcola emithini kungasisiza siqonde izindlela zokungcola futhi kunikeze isisekelo sokuthuthukisa inqubo yokukhiqiza.Ngakho-ke, ukulungiswa nokuhlukaniswa kokungcola kubaluleke kakhulu ocwaningweni nasekuthuthukisweni kwezidakamizwa.
Kodwa-ke, okuqukethwe kokungcola emthini kuphansi, umthombo ubanzi, futhi isakhiwo sifana kakhulu nengxenye eyinhloko.Yibuphi ubuchwepheshe obungasetshenziswa ukuhlukanisa nokuhlanza konke ukungcola emthini ngamunye ngamunye futhi ngokushesha?Yiziphi izindlela nezindlela ezisetshenziswayo ukuze kuqinisekiswe ukwakheka kwalokhu kungcola?Lobu ubunzima kanye nenselelo ebhekene namayunithi amaningi emithi, ikakhulukazi amabhizinisi emithi yezitshalo kanye nemithi yobunikazi yamaShayina.
Ngokusekelwe ezidingweni ezinjalo, inkampani yethule izinsiza zokuhlukanisa ukungcola kwezidakamizwa kanye nezinsizakalo zokuhlanza.Ngokuthembela ku-nuclear magnetic resonance, i-mass spectrometry nezinye izinto zokusebenza nobuchwepheshe, inkampani ingakwazi ukubona ngokushesha ukwakheka kwezinhlanganisela ezihlukanisiwe, ukuze ihlangabezane nezidingo zamakhasimende.
I-SPF Animal Experiment
Indawo yokwakhiwa kwendawo yokuhlolwa kwezilwane ingamamitha-skwele ayi-1500, okuhlanganisa namamitha-skwele angama-400 wendawo yokuhlola yezinga le-SPF kanye namamitha-skwele ayi-100 welebhu yeseli yezinga le-P2.Iholwa ososayensi base-China Pharmaceutical University, yakha ithimba lezobuchwepheshe elibalulekile elinenani labantu ababuyayo.Nikeza amamodeli ezilwane ekhwalithi ephezulu, idizayini yokuhlola, amaphrojekthi aphelele kanye nezinye izinsizakalo zocwaningo lwesayensi ye-biomedical, ukufundisa nokuthuthukiswa kwezimboni.
Ububanzi Bebhizinisi
1. Ukuphakelwa kwezilwane ezincane
2. Ukumodela izifo zezilwane
3. Ukunikezwa kwephrojekthi yasekolishi
4. Ukuhlolwa kwe-Pharmacodynamic ku-vivo
5. Ukuhlolwa kwe-Pharmacokinetic
6. Isevisi yokuhlola iseli yesimila
Amandla Ethu
1. Gxila ekuhloleni kwangempela
2. Qinisekisa ngokuqinile inqubo
3. Sayina ngokuqinile isivumelwano sobumfihlo
4. Ilabhorethri Yakho ngaphandle kwezixhumanisi eziphakathi nendawo
5. Ithimba lochwepheshe bezobuchwepheshe liqinisekisa ikhwalithi yokuhlola
Indawo yokuhlola ye-SPF, ukuphakelwa komuntu okwabelwe ngokukhethekile, inqubekelaphambili yokuhlola yokulandelela ngesikhathi sangempela
