I-Methylophiopogonanone B
Ukusetshenziswa kwe-Methylophiopogonanone B
I-Methylophiopogonone B, i-isodihydroflavone ephezulu, ekhishwe empandeni ye-Ophiopogon japonicus, inomthamo ophezulu wokulwa ne-antioxidant.I-Methylophiopogonone B inyusa i-GTP Rho futhi isebenza ngendlela yokusayina ye-Rho.I-Methylophiopogonone B yenza izinguquko ze-cell morphological, okuhlanganisa ukufinyela kwe-dendritic kanye nokwakheka kwe-fiber yokucindezeleka, ngokusebenzisa ukuhlelwa kabusha kwe-actin cytoskeleton.
Igama likaMethylophiopogonanone B
Igama lesiNgisi:
(3R)-5,7-Dihydroxy-3-(4-methoxybenzyl)-6,8-dimethyl-2,3-dihydro-4 H-chromen-4-one
Umsebenzi webhayoloji we-Methylophiopogonanone B
Incazelo: i-methylophiopogonone B, i-isodihydroflavone ephezulu, ekhishwe empandeni ye-Ophiopogon japonicus, inamandla aphezulu e-antioxidant.I-Methylophiopogonone B inyusa i-GTP Rho futhi isebenza ngendlela yokusayina ye-Rho.I-Methylophiopogonone B yenza izinguquko ze-cell morphological, okuhlanganisa ukufinyela kwe-dendritic kanye nokwakheka kwe-fiber yokucindezeleka, ngokusebenzisa ukuhlelwa kabusha kwe-actin cytoskeleton.
Izigaba Ezihlobene: inkundla yocwaningo > > okunye
indlela yokubonisa > > I-G protein ehambisana ne-receptor /
G protein > > RAS
Izikhombo: [1] Wang Y, et al.I-Homoisoflavonoids kanye ne-Antioxidant
Umsebenzi we-Ophiopogon japonicus Root.
Ito Y, et al.I-ejenti yenoveli, i-methylophiopogonanone B,
ikhuthaza ukusebenza kwe-Rho kanye ne-tubulin depolymerization.I-Mol Cell Biochem.2007 Mar;297(1-2):121-9.I-Epub 2006 Okthoba 7.
Izakhiwo ze-Physicochemical ze-Methylophiopogonanone B
Ubukhulu: 1.285
Indawo yokubilisa: 554.5 ± 49.0 ° C ku-760 mmHg
I-Molecular Formula: C19H20O5
Isisindo se-molecule: 328.359
Iphoyinti elikhanyayo: 201.5 ± 23.3 ° C
Isisindo esinembile: 328.131073
I-PSA: 75.99000
Inombolo yepholisi: 5.22
Umfutho we-steam: 0.0 ± 1.6 mmHg ku-25 ° C
Inkomba ye-refractive: 1.617
Isevisi ye-Yongjian
Isevisi Eyenziwe Ngezifiso Yezikhombo Zezinto Zemithi Yendabuko YamaShayina
I-Jiangsu Yongjian Pharmaceutical Technology Co., Ltd. ibambe iqhaza kakhulu ocwaningweni oluyisisekelo lwezinto ezisebenzayo zemithi yendabuko yamaShayina iminyaka engaphezu kweyishumi.Kuze kube manje, inkampani yenze ucwaningo olunzulu ngezinhlobo ezingaphezu kwe-100 zemithi yendabuko yaseShayina evame ukusetshenziswa, futhi yakhipha izinkulungwane zezingxenye zamakhemikhali.
Inkampani inabasebenzi abaphezulu be-R & D kanye nemishini yokuhlola nokuhlaziya ephelele embonini, futhi isize amakhulu ezikhungo zocwaningo lwesayensi.Ingakwazi ukuhlangabezana nezidingo zamakhasimende ngokushesha nangempumelelo
Ukwehlukaniswa Kokungcola Kwezidakamizwa, Isevisi Yokulungiselela kanye Nesakhiwo Sokuqinisekisa
Ukungcola kwezidakamizwa kuhlobene kakhulu nekhwalithi, ukuphepha kanye nokuzinza kwezidakamizwa.Ukulungiswa nokuqinisekiswa kwesakhiwo sokungcola emithini kungasisiza siqonde izindlela zokungcola futhi kunikeze isisekelo sokuthuthukisa inqubo yokukhiqiza.Ngakho-ke, ukulungiswa nokuhlukaniswa kokungcola kubaluleke kakhulu ocwaningweni nasekuthuthukisweni kwezidakamizwa.
Kodwa-ke, okuqukethwe kokungcola emthini kuphansi, umthombo ubanzi, futhi isakhiwo sifana kakhulu nengxenye eyinhloko.Yibuphi ubuchwepheshe obungasetshenziswa ukuhlukanisa nokuhlanza konke ukungcola emthini ngamunye ngamunye futhi ngokushesha?Yiziphi izindlela nezindlela ezisetshenziswayo ukuze kuqinisekiswe ukwakheka kwalokhu kungcola?Lobu ubunzima kanye nenselelo ebhekene namayunithi amaningi emithi, ikakhulukazi amabhizinisi emithi yezitshalo kanye nemithi yobunikazi yamaShayina.
Ngokusekelwe ezidingweni ezinjalo, inkampani yethule izinsiza zokuhlukanisa ukungcola kwezidakamizwa kanye nezinsizakalo zokuhlanza.Ngokuthembela ku-nuclear magnetic resonance, i-mass spectrometry nezinye izinto zokusebenza nobuchwepheshe, inkampani ingakwazi ukubona ngokushesha ukwakheka kwezinhlanganisela ezihlukanisiwe, ukuze ihlangabezane nezidingo zamakhasimende.
I-SPF Animal Experiment
Indawo yokwakhiwa kwendawo yokuhlolwa kwezilwane ingamamitha-skwele ayi-1500, okuhlanganisa namamitha-skwele angama-400 wendawo yokuhlola yezinga le-SPF kanye namamitha-skwele ayi-100 welebhu yeseli yezinga le-P2.Iholwa ososayensi base-China Pharmaceutical University, yakha ithimba lezobuchwepheshe elibalulekile elinenani labantu ababuyayo.Nikeza amamodeli ezilwane ekhwalithi ephezulu, idizayini yokuhlola, amaphrojekthi aphelele kanye nezinye izinsizakalo zocwaningo lwesayensi ye-biomedical, ukufundisa nokuthuthukiswa kwezimboni.
Ububanzi Bebhizinisi
1. Ukuphakelwa kwezilwane ezincane
2. Ukumodela izifo zezilwane
3. Ukunikezwa kwephrojekthi yasekolishi
4. Ukuhlolwa kwe-Pharmacodynamic ku-vivo
5. Ukuhlolwa kwe-Pharmacokinetic
6. Isevisi yokuhlola iseli yesimila
Amandla Ethu
1. Gxila ekuhloleni kwangempela
2. Qinisekisa ngokuqinile inqubo
3. Sayina ngokuqinile isivumelwano sobumfihlo
4. Ilabhorethri Yakho ngaphandle kwezixhumanisi eziphakathi nendawo
5. Ithimba lochwepheshe bezobuchwepheshe liqinisekisa ikhwalithi yokuhlola
Indawo yokuhlola ye-SPF, ukuphakelwa komuntu okwabelwe ngokukhethekile, inqubekelaphambili yokuhlola yokulandelela ngesikhathi sangempela
