Imikhiqizo

I-Naringin iyi-aglycone ye-naringin futhi ingeye-dihydroflavonoids.Inemisebenzi ye-antibacterial, anti-inflammatory, scavenging free radical, i-antioxidant, ukukhwehlela kanye ne-expectorant, ukwehlisa i-lipid yegazi, i-anti-cancer, i-anti-tumor, i-antispasmodic kanye ne-cholagogic, ukuvimbela nokwelashwa kwezifo zesibindi, ukuvinjelwa kwe-platelet coagulation, i-anti. i-atherosclerosis nokunye.Ingasetshenziswa kabanzi emithini, ekudleni nakweminye imikhakha.

I-antibacterial
Inomphumela onamandla we-antibacterial ku-Staphylococcus aureus, i-Escherichia coli, i-dysentery kanye ne-typhoid bacillus.I-Naringin nayo inomphumela kusikhunta.Ukufafaza i-1000ppm elayisini kunganciphisa ukutheleleka kweMagnaporthe grisea ngo-40-90%, futhi akunabo ubuthi kubantu nasemfuyweni.

I-Antiinflammatory
Amagundane ajovwe nge-intraperitoneally nge-20mg / kg nsuku zonke, okwakuvimbela kakhulu inqubo yokuvuvukala ebangelwa ukufakwa kwebhola leboya.Galatiya et al.Kutholwe ukuthi iqembu ngalinye lomthamo we-naringin linomphumela wokunqanda ukuvuvukala ngokuhlolwa kwethebhulethi yendlebe yegundane, futhi umphumela wokulwa nokuvuvukala uyanda ngokunyuka komthamo.Izinga lokuvinjelwa kweqembu lethamo eliphezulu lalingu-30.67% elinomehluko wokujiya kanye nama-38% anomehluko wesisindo.[4] Feng Baomin et al.Isigaba sesi-3 se-dermatitis esiyenziwe kumagundane ngendlela ye-DNFB, sabe sesinikeza i-naringin ngomlomo izinsuku ezingu-2 ~ 8 ukuze kubonwe amazinga okuvimbela esigaba esisheshayo (IPR), isigaba sekwephuzile (i-LPR) kanye nesigaba se-ultra late (VLPR).I-Naringin inganqanda ngempumelelo i-edema yendlebe ye-IPR ne-VLPR, futhi inenani elithile lokuthuthuka ekunqandeni ukuvuvukala.

Ukulawulwa kwamasosha omzimba
I-Naringin igcina ibhalansi efanelekile yokucindezela kwe-oxidative ngesikhathi esithile nasezifundeni ezithile ngokulawula ukugeleza kwama-electron ku-mitochondria.Ngakho-ke, umsebenzi we-immunomodulatory we-naringin uhlukile kuzithuthukisi zokuzivikela ezilula zendabuko noma ama-immunosuppressants.Isici salo ukuthi singabuyisela isimo sokuzivikela esingalingani (isimo se-pathological) esimweni esiseduze sokulinganisela komzimba (isimo somzimba), Esikhundleni sokuthuthukisa unilaterally noma ukuvimbela impendulo yokuzivikela komzimba.

Umthetho wokuya esikhathini kwabesifazane
I-Naringin inomsebenzi ofana nezidakamizwa ezingezona ukuvuvukala.Inganciphisa ukuhlanganiswa kwe-prostaglandin PGE2 ngokuvimbela i-cyclooxygenase Cox, futhi idlale indima ye-antipyretic, i-analgesic kanye nokunciphisa ukuvuvukala.
Ngokusekelwe kumphumela we-estrogen ofana nowe-naringin, i-naringin ingasetshenziswa ekwelapheni esikhundleni se-estrogen kwabesifazane abangemva kokuya esikhathini ukuze kugwenywe ukusabela okubi okungathi sína okubangelwa ukusebenzisa i-estrogen isikhathi eside.

Imiphumela yokukhuluphala ngokweqile
I-Naringin inomphumela osobala wokwelapha ku-hyperlipidemia nokukhuluphala.
I-Naringin ingathuthukisa ngokuphawulekayo ukuhlushwa kwe-cholesterol eningi ye-plasma, ukugxiliswa kwe-TG (triglyceride) kanye nokugxila kwamafutha amahhala kumagundane akhuluphele.Kutholwe ukuthi i-naringin ingakhuphula ilawula isamukeli esicushiwe se-monocyte peroxisome proliferator kumagundane anamafutha aphezulu δ， Yehlisa izinga le-lipid yegazi.
Ngokuhlolwa komtholampilo, kwatholakala ukuthi iziguli ezine-hypercholesterolemia zathatha i-capsule eyodwa equkethe i-400mg i-naringin nsuku zonke amasonto ayi-8.Ukugxila kwe-TC ne-LDL cholesterol ku-plasma kwehle, kodwa ukugxila kwe-TG ne-HDL cholesterol akuzange kushintshe kakhulu.
Ekuphetheni, i-naringin ingathuthukisa i-hyperlipidemia, eye yaqinisekiswa kahle ekuhlolweni kwezilwane kanye nokuhlolwa komtholampilo.

Ukususa ama-radicals mahhala kanye ne-antioxidation
I-DPPH (i-dibenzo bitter acyl radical) iyi-radical yamahhala ezinzile.Amandla ayo okuqeda ama-radicals mahhala angahlolwa ngokuncishiswa kwawo okungu-517 nm.[6] U-Kroyer wafunda umphumela we-antioxidant we-naringin ngokusebenzisa izivivinyo futhi waqinisekisa ukuthi i-naringin inomphumela we-antioxidant.[7] UZhang Haide et al.Ivivinye inqubo ye-lipid peroxidation ye-LDL nge-colorimetry kanye nekhono lokuvimbela ukuguqulwa kwe-oxidative ye-LDL.I-Naringin ikakhulukazi i-chelates i-Cu2 + ngamaqembu ayo ayi-3-hydroxyl kanye ne-4-carbonyl, noma ihlinzeka nge-proton kanye ne-free radical neutralization, noma ivikela i-LDL ku-lipid peroxidation ngokusebenzisa i-self oxidation.U-Zhang Haide nabanye bathole ukuthi i-naringin inomphumela omuhle wokulahla ama-radical mahhala ngendlela ye-DPPH.Umphumela wamahhala wokulahla ungabonakala nge-hydrogen oxidation ye-naringin ngokwayo.[8] Peng Shuhui et al.Kusetshenziswe imodeli yokuhlola ye-riboflavin ekhanyayo (IR) - i-nitrotetrazolium chloride (NBT) - i-spectrophotometry ukuze ifakazele ukuthi i-naringin inomphumela osobala wokuthungatha ohlotsheni lwe-oksijini osebenzayo i-O2 -, enamandla kunaleyo ye-ascorbic acid ekulawuleni okuhle.Imiphumela yokuhlolwa kwezilwane ibonise ukuthi i-naringin ibe nomthelela oqinile wokuvimbela i-lipid peroxidation ebuchosheni begundane, inhliziyo nesibindi, futhi ingathuthukisa kakhulu umsebenzi we-superoxide dismutase (SOD) egazini legundane lonke.

Ukuvikelwa Kwenhliziyo
I-Naringin ne-naringin ingakhuphula imisebenzi ye-acetaldehyde reductase (ADH) ne-acetaldehyde dehydrogenase (ALDH), inciphise okuqukethwe kwe-triglycerides esibindini kanye ne-cholesterol ephelele egazini nasesibindini, ikhulise okuqukethwe kwe-high density lipoprotein cholesterol (HDLC), ikhulise isilinganiso. ye-HDLC ku-cholesterol ephelele, futhi yehlise inkomba ye-atherogenic ngesikhathi esifanayo, i-Naringin ingakhuthaza ukuthuthwa kwe-cholesterol isuka ku-plasma iye esibindini, i-bile secretion and excretion, futhi ivimbele ukuguqulwa kwe-HDL ku-VLDL noma i-LDL.Ngakho-ke, i-naringin inganciphisa ingozi ye-arteriosclerosis nesifo senhliziyo.I-Naringin inganciphisa okuqukethwe kwe-cholesterol ephelele ku-plasma futhi iqinise imetabolism yayo.

Umphumela we-Hypolipidemic
UZhang Haide et al.I-serum cholesterol (TC), i-low density lipoprotein cholesterol (LDL-C), i-plasma high density lipoprotein cholesterol (HDL-C), i-triglyceride (TG) nezinye izinto zamagundane ngemuva kokuphathwa ngomthambo ngokuhlolwa kwezilwane. i-serum TC, TG kanye ne-LDL-C kanye nokwandisa i-serum HDL-C ngomthamo othile, okubonisa ukuthi i-naringin ibe nomthelela wokunciphisa i-lipid yegazi kumagundane.[

Umsebenzi we-Antitumor
I-Naringin ingalawula ukusebenza kokuzivikela komzimba futhi ivimbele ukukhula kwesimila.I-Naringin inomsebenzi ku-rat leukemia L1210 kanye ne-sarcoma.Imiphumela yabonisa ukuthi isilinganiso se-thymus / isisindo somzimba samagundane sikhuphuke ngemuva kokuphathwa ngomlomo kwe-naringin, okubonisa ukuthi i-naringin ingathuthukisa ukusebenza kokuzivikela komzimba.I-Naringin ingalawula izinga lama-T lymphocyte, ilungise ukukhubazeka kwesibili kokuzivikela komzimba okubangelwa isimila noma i-radiotherapy kanye nokwelashwa ngamakhemikhali, futhi ithuthukise umphumela wokubulala wamangqamuzana omdlavuza.Kubikwa ukuthi i-naringin ingakhuphula isisindo se-thymus kumagundane anomdlavuza we-ascites, okuphakamisa ukuthi ingathuthukisa ukusebenza kwamasosha omzimba futhi ihlanganise ikhono layo langaphakathi lokulwa nomdlavuza.Kutholwe ukuthi i-pomelo peel extract inomphumela ovimbelayo ku-S180 sarcoma, futhi izinga lokuvimbela isimila lalingu-29.7%.

I-Antispasmodic ne-cholagogic
Inomphumela oqinile kuma-flavonoids.I-Naringin iphinde ibe nomthelela oqinile ekwandiseni ukukhishwa kwenyongo ezilwaneni ezihlolwayo.

I-Antitussive And Expectorant Effect
Kusetshenziswa i-phenol ebomvu njengenkomba yomphumela wokuqeda izifo, ucwaningo lubonisa ukuthi i-naringin inokukhwehlela okuqinile kanye nomphumela we-expectorant.

Isicelo somtholampilo
Isetshenziselwa ukwelapha izifo ezibangelwa amagciwane, izidakamizwa zokulalisa kanye nezidakamizwa ezilwa nomdlavuza.
Ifomu lomthamo wesicelo: i-suppository, lotion, umjovo, ithebhulethi, i-capsule, njll.