Izindaba

Muva nje, kukhishwe inguqulo entsha Yohlu Lwezidakamizwa Zomshuwalense Wezempilo Kazwelonke, kwengeza izinhlobo ezintsha eziyi-148, okuhlanganisa nemithi yaseNtshonalanga engama-47 kanye nemithi yobunikazi yaseShayina engu-101.Inombolo entsha yemithi yobunikazi yamaShayina ingaphezu kokuphindwe kabili kunemithi yaseNtshonalanga.Inombolo yemithi yobunikazi yamaShayina kanye nemithi yaseNtshonalanga kukhathalogi yomshwalense wezokwelapha iyafana okokuqala ngqa.Ukuqinisekisa kwezwe kwemithi yobunikazi baseShayina kanye nokwesekwa kwayo kokuthuthukiswa.Kodwa ngesikhathi esifanayo, ezinye izidakamizwa ezinemiphumela engalungile yokwelapha kanye nokuhlukumeza okusobala zikhishiwe ohlwini.Eziningi zazo ziyimithi yamaShayina ephethwe.Ngakho-ke, ukuze kugwenywe ukuqedwa yimakethe yemithi, ukuthuthukiswa kwemithi yamaShayina kufanele kuqaliswe!

Ukuthuthukiswa kwemithi yamaShayina

1. Umgomo kazwelonke uyavumelana nesimo
Eminyakeni yamuva nje, izinqubomgomo nemithetho yezwe lami yemithi yendabuko ishicilelwe njalo, futhi iye yathuthukiswa ngokuqhubekayo futhi yathuthukiswa, ihlinzeka ngomklamo omuhle wezinga eliphezulu kanye nesiqondiso sokuthuthukiswa kwesikhathi eside kwemboni yezokwelapha yendabuko yaseShayina yezwe lami.
Inqubo esebenzayo yokugunyazwa kwemithi yamaShayina ikhombisa ukuzimisela namandla ezwe lami ukusekela nokukhuthaza ukuthuthukiswa kwemithi yamaShayina.Umbuso usebenzisa izenzo ukukholisa umphakathi kanye namabhizinisi ukuthi imithi yendabuko yamaShayina, ingcebo eyigugu yesizwe saseShayina, izoqhutshekelwa phambili kangcono ukuze kuzuze uquqaba lwabantu.

2. Ucwaningo lwesimanje seluseduze
Kusukela ngo-2017, izifundazwe ezihlukene ziye zakhipha izaziso ngokulandelana zokumisa noma ukuguqula izidakamizwa ezisizayo ezihlukahlukene, inhloso eyinhloko okuwukunciphisa izinkokhelo, nokugxila ekuqapheni izidakamizwa ezinemiphumela engalungile yokwelapha, imithamo emikhulu, noma amanani abizayo.

NgoMashi walo nyaka, kwasungulwa umuthi wokuqala emhlabeni osekelwe ebufakazini emithini yendabuko yamaShayina.Lesi sikhungo sizohlinzeka ngobufakazi bokusebenza nokuphepha kwemithi yendabuko yamaShayina.Uma ukufana kwemithi esekelwe ebufakazini kanye nemithi yendabuko yaseShayina ingahlanganiswa ngokwemvelo ibe icala, ngeke nje ithuthukise kakhulu izinga lokuxilongwa nokwelashwa emtholampilo, kodwa futhi kufakazela intengo yomuthi wemithi yendabuko yamaShayina kanye nesikhundla phakathi kwamazwe omhlaba. inkundla yokuhlinzeka ngohlelo lwesayensi namathuba.

NgoJulayi, Ikhomishana Yezempilo Kazwelonke yakhipha “Isaziso Ngokuphrinta Nokusabalalisa Iqoqo Lokuqala Lohlu Lwezidakamizwa Ezingukhiye Likazwelonke (Izidakamizwa Zekhemikhali Nemikhiqizo Yebhayoloji) Sokuqapha Okubalulekile Kokusetshenziswa Okunengqondo”.Isaziso siyingozi kakhulu ekusetshenzisweni kwemithi yobunikazi baseShayina.Imithi yaseNtshonalanga ayikwazi ukunikeza imithi yaseShayina.Umuthi welungelo lobunikazi, lesi sinyathelo akukona okokuvimbela ukusetshenziswa kwemithi yobunikazi yamaShayina, kodwa ukulawula ukusetshenziswa kwemithi yobunikazi yamaShayina.

Ngaphansi kwezimo ezinjalo, uma imithi yamaShayina ephathelene nempahla ingakwazi ukwengeza imithi esekelwe ebufakazini, iphule imigoqo phakathi komuthi wendabuko waseShayina kanye nemithi yaseNtshonalanga, futhi ifake imihlahlandlela yezokwelapha nokuvumelana, ingasiza imithi yamaShayina ukwephula isimo ngokushelela!

Ngaphansi kwesimo esisha se-"One Belt One Road", ukuhwebelana kwamazwe ngamazwe kwezokwelapha zaseShayina kunamandla amakhulu
Ngo-2015, uNksz Tu Youyou wawina uMklomelo KaNobel wePhysiology noma Medicine ngokusungulwa kwe-artemisinin, eyandisa ithonya lomuthi waseShayina phesheya kwezilwandle.Nakuba imithi yaseShayina ibe negalelo elimangalisayo ekuthuthukisweni kwemithi yomhlaba wonke, ukuhwebelana kwamazwe ngamazwe kwezokwelapha zaseShayina kusabhekene nobunzima obuningi njengesiko namazinga obuchwepheshe.

Esokuqala yinkinga yesiko lezokwelapha.Ukwelashwa kwe-TCM kugcizelela ukuhlukaniswa kwe-syndrome nokwelashwa, okwelapha izifo ngokuhlaziywa nokulungiswa komzimba womuntu;kuyilapho imithi yaseNtshonalanga igxile ezinhlotsheni zezifo ezilula kanye nokwelashwa kwendawo, futhi iziqeda ngokuthola imbangela yalesi sifo.Okwesibili ubunzima bezindinganiso zobuchwepheshe.Imithi yaseNtshonalanga inaka ubunye, ukunemba kanye nedatha.Ukwamukelwa kwemithi kusekelwe ezidingweni zokuphepha nokusebenza ngempumelelo kwezidakamizwa.Ama-ejensi okuphatha imithi aseNtshonalanga aphinde aphakamise amazinga ahambisanayo okwamukelwa emithini yaseShayina.Nokho, imithi eminingi yamaShayina okwamanje isezweni lami.Ucwaningo nentuthuko kwahlala kuphela esigabeni sokubhekwa kanzima, i-GLP ehambisanayo ne-GCP ayizange isungulwe, kanye nokuhlolwa kokusebenza komtholampilo okusekelwa idatha yesayensi etholwe ezivivinyweni zomtholampilo bekungekho.Ngaphezu kwalokho, ukuncintisana kwemakethe yamazwe ngamazwe okushubile kuye kwaletha izinselele ezinzima embonini yezokwelapha yaseShayina, futhi ukuphakama kobunzima obuhlukahlukene kuholele ekunciphiseni ukwenziwa kwemithi yamaShayina emazweni ngamazwe.

Ngo-2015, izwe lami lakhipha "Umbono Nezenzo Zokukhuthaza Ukwakhiwa Ngokuhlanganyela Kwebhande Lezomnotho Lomgwaqo Kasilika kanye Nomgwaqo Kasilika Wasolwandle Wama-21".Umgomo kazwelonke othi "One Belt One Road" waphakanyiswa ngokusemthethweni.Lona "Umgwaqo Kasilika omusha" wokwenza imboni yezwe lami ibe namazwe ngamazwe futhi ikhuthaza ukuthuthukiswa komnotho wezwe lami sekungene kwelinye izinga eliphezulu.Umuthi wendabuko waseShayina wezwe lami ubambe iqhaza ekwakhiweni kwe-“Belt and Road”.Ngohlelo lwenqubomgomo ye-"Going Global" yesiko lemithi yamaShayina, ikhuthaza ifa kanye nokusungulwa kwemithi yamaShayina, futhi isheshisa ukuhlanganiswa nokuthuthukiswa kokucabanga kwemithi yaseShayina yasekuqaleni kanye nobuchwepheshe besimanje.Lelisu linikeza umfutho wangaphakathi kanye namathuba amasha okwenziwa kwamanye amazwe kwemithi yaseShayina.

Ngokwezibalo ze-China Customs, ngo-2016, imikhiqizo yezwe lami yendabuko yaseShayina ithunyelwe emazweni nasezifundeni ezingu-185, futhi izinhlangano ezifanele zamazwe ahambisana nomzila zisayine izivumelwano zokubambisana kwemithi yamaShayina engama-86 nezwe lami.Izinga lokukhula kokuthunyelwa kwemikhiqizo yemithi yendabuko yamaShayina likhula kancane kancane.Kungabonakala ukuthi ngaphansi kwesimo esisha se "Ibhande Elilodwa Umgwaqo Owodwa", ukuthengiswa kwamanye amazwe kwemithi yaseShayina kuyathembisa!

1.Research on Modernization of Traditional Chinese Medicine
Inhloso yokwenziwa kwesimanje kwemithi yamaShayina ukusebenzisa ngokugcwele izindlela nezindlela zesayensi nobuchwepheshe besimanje ngesisekelo sokuqhubekisela phambili izinzuzo nezici zemithi yamaShayina, nokufunda ezindinganisweni nasezinkambisweni zezokwelapha zamazwe ngamazwe, ukucwaninga nokuthuthukisa Imikhiqizo yemithi yamaShayina engangena ngokusemthethweni emakethe yemithi yamazwe ngamazwe, kanye nokuthuthukisa imakethe yamazwe ngamazwe yemithi yamaShayina.Ukuncintisana kwemakethe.
Ukwenziwa kwesimanjemanje kwemithi yendabuko yamaShayina kuwubunjiniyela besistimu eyinkimbinkimbi.Ngokochungechunge lwezimboni, ingahlukaniswa ibe phezulu (umhlaba/izinsiza), phakathi nendawo (ifekthri/ukukhiqiza) kanye nomfula ongezansi (ucwaningo/umtholampilo).Njengamanje, ukuthuthukiswa kwemithi yendabuko yamaShayina akulingani, kubonisa isimo "esinzima phakathi nokukhanya emikhawulweni emibili".Ucwaningo lokwenziwa kwesimanjemanje kwemithi yendabuko yamaShayina ehlanganiswe nokusebenza komtholampilo isixhumanisi esibuthakathaka isikhathi eside, kodwa futhi isixhumanisi esibaluleke kakhulu enqubweni yokwenziwa kwesimanjemanje kwemithi yendabuko yamaShayina.Okuqukethwe okuyinhloko kocwaningo lwamanje ochungechungeni lwezimboni ezansi nomfula yimiyalelo eyinhlanganisela, okuhlanganisa nocwaningo lwezingxenye zamakhemikhali emithi yendabuko yamaShayina, okungukuthi, ucwaningo ngokwakheka kwawo kwamakhemikhali kanye nocwaningo mayelana nomthetho wokushintshwa kokwakheka ngesikhathi sokucubungula;ucwaningo lobuchwepheshe bokulungiselela imithi yamaShayina, njengokuthuthukiswa, ukuthuthukiswa kanye nokusha kobuchwepheshe bendabuko.Ukuthuthukiswa kwamafomu omthamo, njll.;ucwaningo lwe-pharmacological lwemithi yendabuko yamaShayina, okungukuthi, ukutadisha izakhiwo zokwelapha zendabuko kanye ne-pharmacology yokuhlola yesimanje;ukuhlolwa okuhloswe kokusebenza komtholampilo.

2.Ucwaningo mayelana nezithako zemithi yendabuko yamaShayina kadokotela
Ngenxa yokuthi izingxenye zamakhemikhali eziqukethwe emithini yaseShayina nezinhlanganisela zayo ziyinkimbinkimbi kakhulu, lokho okubizwa ngokuthi "izithako ezisebenzayo" ezishiwo noma ezikalwa emazingeni amanje ekhwalithi yemithi eminingi yamaShayina kanye nezinhlanganisela zayo ngokuvamile ziyizithako eziyinhloko zomuthi oyinhloko noma okuthiwa i izithako zenkomba, ezinganele.Ubufakazi bufakazela ukuthi iyisithako esisebenzayo.Kusetshenziswa izindlela zesimanje zokuhlaziya nezindlela zokuhlonza kanye nobuchwepheshe obusizwa ngekhompiyutha ukwenza ukuhlolwa kwe-high-throughput screening (HTS) kanye nezimpawu (okuhlanganisa nokuchazwa kwamakhemikhali nebhayoloji) kolwazi lwengxenye enkulu emithini yendabuko yamaShayina kanye nemiyalelo yayo eyinhlanganisela, kanye nokuhlola isisekelo sezinto ukusebenza kahle komuthi wendabuko waseShayina wucwaningo lokwenziwa kwesimanjemanje kwemithi yendabuko yamaShayina.Isinyathelo esibalulekile.Ngokuthuthuka kancane kancane kwe-HPLC, i-GC-MS, i-LC-MS, nobuchwepheshe obuzibuthe benuzi, kanye nokwethulwa okuqhubekayo kwemibono nezindlela ezisezingeni eliphezulu ezifana ne-chemometrics, ithiyori yokuqaphela iphethini, i-metabolomics, ikhemikhali ye-serum yokwelapha, njll. , Kungenzeka ukuqaphela ukwahlukaniswa okuku-inthanethi kanye nokuhlaziywa kwamaqembu amaningi enhlanganisela kumasampula emithi yendabuko yamaShayina, ukuthola idatha yekhwalithi/ubuningi nolwazi, futhi kucaciswe isisekelo esisebenzayo semithi yesiShayina kanye nemiyalelo eyinhlanganisela.

3. Ucwaningo ngokusebenza ngempumelelo kanye nendlela yemithi ye-Chinese herbal compound
Ngaphezu kwalolu cwaningo olubalulwe ngenhla mayelana nezingxenye zekhompiyutha, ucwaningo ngokusebenza ngempumelelo kanye nendlela yenhlanganisela futhi luwucwaningo lokuqukethwe olubalulekile.Ukusebenza kwenhlanganisela kuqinisekiswa ngamamodeli amaseli namamodeli ezilwane, ngokusebenzisa i-metabolomics, i-proteomics, i-transcriptomics, i-phenomics, ne-genomics.Ukucacisa incazelo yesayensi yomuthi wendabuko waseShayina kanye nokubeka isisekelo esiqinile sesayensi sencazelo yesayensi yomuthi wendabuko waseShayina kanye nokwenziwa kwamanye amazwe kwemithi yendabuko yamaShayina.

4. Ucwaningo Ngemithi Yokuhumusha Yemithi Yendabuko YamaShayina
Ngekhulu lama-21, ucwaningo lwemithi yokuhumusha luwumkhuba omusha ekuthuthukisweni kwesayensi yempilo yamazwe ngamazwe.Isiphakamiso kanye nenqubekelaphambili yocwaningo lwemithi yokuhumusha inikeza isiteshi "esiluhlaza" sokuhlanganiswa kwemithi, okuyisisekelo kanye nomtholampilo, futhi sinikeza ithuba elisha lokwenza ucwaningo lwemithi yamaShayina lube lulusuku lwakamuva."Ikhwalithi, ikhwalithi, izakhiwo, ukusebenza kahle, kanye nokusetshenziswa" yizici eziyisisekelo zomuthi waseShayina, ezihlanganisa zonke izindinganiso zemithi yamaShayina ezihlangene futhi eziphilayo.Ukwenza ucwaningo olugxile ezidingweni zomtholampilo ngokuhlanganisa "ikhwalithi-ikhwalithi-ukusebenza-ukusebenza-ukusebenza-ukusetshenziswa" komuthi wendabuko waseShayina kuyindlela ebalulekile yokuthi ukwenziwa kwesimanje kwemithi yendabuko yamaShayina kusondele emtholampilo ngokushesha ngangokunokwenzeka.Kuphinde futhi kuyisidingo esingenakugwenywa sokuguqulwa kocwaningo lwemithi yamaShayina yendabuko lube yinkambiso yomtholampilo, futhi kuwukubuya kocwaningo lwemithi yendabuko yamaShayina yesimanje.Ukubonakaliswa okubalulekile kwemodeli yokucabanga yasekuqaleni yemithi yamaShayina, ngakho-ke kunokubaluleka okubalulekile kwamasu nokusebenzayo.

Ucwaningo ngokwenziwa kwesimanjemanje kwemithi yamaShayina ayiyona nje indaba yesayensi kuphela, kodwa futhi ihlobene nentuthuko yonke yemboni yezemithi yezwe lami.Ngaphansi kwesimo sonke esivumayo sezinqubomgomo zikazwelonke, ucwaningo mayelana nesimanjemanje somuthi wendabuko waseShayina kanye nokwenziwa kwawo ngamazwe ngamazwe lubalulekile.Yiqiniso, ayihlukaniseki kule nqubo.Imizamo ehlanganyelwe yabo bonke abacwaningi besayensi abaphambili!

Ngokubheka ucwaningo lwesimanje lwemiyalelo ehlanganisiwe yemithi yamaShayina, i-Puluo Medicine ifinyeze iqoqo lemibono yocwaningo emisha futhi engenzeka:

Okokuqala, sebenzisa amamodeli ezilwane ukuze kuqinisekiswe ukusebenza kahle, futhi unqume imiphumela kanye nesilinganiso ngokusebenzisa izinkomba ezihlobene nesifo;okwesibili, sebenzisa ukubikezela kwe-compound-target-pathway okusekelwe ku-pharmacology yenethiwekhi, sebenzisa i-metabolomics, i-proteomics, i-transcriptomics, ne-phenotypes, ucwaningo lwe-Genomics ukuze ubikezele isiqondiso / indlela yokulawula inhlanganisela;bese usebenzisa amamodeli wamaseli nezilwane ukuze uthole futhi uqinisekise isiqondiso somthetho ngokutholwa kwezinto ezivuvukalayo, ingcindezi ye-oxidative, njll., futhi wenze ukutholwa okuhlosiwe ngokuthola ama-molecule esignali, izici zokulawula, kanye nokuqukethwe kofuzo okuhlosiwe Nokuqinisekisa;Okokugcina, sebenzisa isigaba soketshezi esisebenza kahle kakhulu, i-mass spectrometry, njll. ukuze uhlaziye ukwakheka kwenhlanganisela, futhi usebenzise imodeli yeseli ukuze uhlole ama-monomer asebenzayo.