Obtusin
Ukusetshenziswa kwe-Obtusin
I-Obtusin, evela kumbewu ye-cassia, iyisivimbi esikhethayo nesincintisanayo se-monoamine oxidase-A (hmao-a), ene-IC50 ka-11.12 μ M. Ki ngu-6.15.I-Obtusin idlala indima yokuvimbela izifo ze-neurodeergenerative, ikakhulukazi ukukhathazeka nokudangala.
Igama le-Obtusin
Igama lesiNgisi: Obtusin
I-Bioactivity ye-Obtusin
Incazelo: i-obtusin ivela kumbewu ye-cassia.Kuyi-inhibitor ekhetha kakhulu futhi enokuncintisana ye-human monoamine oxidase-A (hmao-a), ene-IC50 ye-11.12 μ M. Ki ngu-6.15.I-Obtusin idlala indima yokuvimbela izifo ze-neurodeergenerative, ikakhulukazi ukukhathazeka nokudangala.
Izigaba Ezihlobene: indlela yesiginali > > indlela yesiginali yemizwa > > i-monoamine oxidase
Inkundla yocwaningo > > izifo zemizwa
Ithagethi: IC50: 11.12 μ M (hMAO-A)[1] Ki: 6.15 (hMAO-A)[1]
Izikhombo: [1] U-Paudel P, et al.I-In Vitro kanye ne-Silico Human Monoamine Oxidase Inhibitory Potential of Anthraquinones, Naphthopyrones, and Naphthalenic Lactones from Cassia obtusifolia Linn Seeds.ACS Omega.2019 Sep 18;4(14):16139-16152.
Izakhiwo ze-Physicochemical Of Obtusin
Ukuminyana: 1.4 ± 0.1 g / cm3
Indawo yokubilisa: 614.9 ± 55.0 ° C ku-760 mmHg
I-Molecular Formula: c18h16o7
Isisindo se-molecule: 344.315
I-Flash Point: 227.0 ± 25.0 ° C
IMisa ngqo: 344.089600
I-PSA: 102.29000
I-logP:4.10
I-Steam Pressure: 0.0 ± 1.8 mmHg ku-25 ° C
Inkomba ye-Refractive: 1.634
Ulwazi Lokuphepha lwe-Obtusin
Ikhodi Yempahla: 2914690090
Izincwadi: Cameron, Donald W;Feutrill, Geoffrey I.;Gamble, Glenn B.;Stavrakis, John Tetrahedron Letters, 1986, vol.27, # 41 p.4999 - 5002
Obtusin Customs
Ikhodi Yempahla: 2914690090
Uhlolojikelele lwesiShayina: Uhlolojikelele lwesiShayina
Isifinyezo:2914690090 amanye ama-quinone。 Izimo zokugadwa:Azikho. I-VAT:17.0%。 Isilinganiso sesaphulelo sentela:9.0%.
Igama LesiNgisi Lamasiko
9,10-Anthracenedione, 1,7-dihydroxy-2,3,8-trimethoxy-6-methyl-
1,7-dihydroxy-2,3,8-trimethoxy-6-methylanthracene-9,10-dione
1,7-Dihydroxy-2,3,8-trimethoxy-6-methyl-9,10-anthraquinone
Ukulawulwa Kwekhwalithi Yomkhiqizo
1. Inkampani ithenge i-nuclear magnetic resonance (Bruker 400MHz) i-spectrometer, i-liquid phase mass spectrometer (LCMS), i-gas phase mass spectrometer (GCMs), i-mass spectrometer (amanzi SQD), ama-chromatographs oketshezi amaningi ahlaziywayo asebenzayo, ama-chromatographs oketshezi alungiselelayo, njll. .
2. Inkampani igcina ukubambisana okuseduze nokuxhumana nezikhungo zocwaningo lwesayensi ezifana ne-Shanghai Institute for control drug, inkundla yenkonzo yomphakathi yaseNanjing biomedical kanye nesikhungo sokuhlaziya nokuhlola se-Shanghai Pharmaceutical Industry Research Institute.
3. Inkampani yenza ngenkuthalo ukugunyazwa kokuhlolwa kwelabhorethri okuvela eceleni, futhi kulindeleke ukuthi ithole Isitifiketi Sokugunyazwa Selabhorethri ye-CNAs ngo-2021.
