I-Ophiopogonin D Cas No.945619-74-9
Ophiopogon Saponin D Igama
Igama lesiNgisi:(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranoside
I-Bioactivity ye-Ophiopogon Japonicus Saponin D
Incazelo:I-Ophiopogon D iyivelakancane yemvelo ye-C29 steroidal glycoside ehlukanisiwe ne-tuber ye-Ophiopogon japonicus.I-Ophiopogonin D iyi-CYP2J3 inducer eyandisa i-CYP2J2 / eets kanye ne-PPAR kumaseli we-umbilical vein endothelial cell (HUVECs) α Ukuvezwa kwe-Ang II kuvimbele kakhulu i-Ang II eyenga i-NF- κ B i-nuclear translocation, I κ B α Down regulation, intracellular Ca2 + ukulayisha ngokweqile kanye nokusebenza kwe-proinflammatory cytokines.I-Ophiopogonin D isetshenziselwe ukwelapha ukuvuvukala kanye nezifo zenhliziyo nemithambo yegazi izinkulungwane zeminyaka.
Izigaba ezifanele
Umzila wamasignali > > ezokuthutha ze-transmembrane > > isiteshi se-calcium
Umkhakha wocwaningo > > isifo senhliziyo
Umzila wamasignali > > umjikelezo weseli / ukulimala kweDNA > > PPAR
Inkambu yocwaningo > > ukuvuvukala / ukungatheleleki
Ithagethi
PPARα
I-NF-kB
Ca2+
Amadokhumenti Ayisethenjwa:[1].Wang L, et al.I-Homo-aro-cholestane, i-furostane ne-spirostane saponins evela ezigabeni ze-Ophiopogonjaponicus.I-Phytochemistry.2017 Apr;136:125-132.
[2].U-Huang X, et al.I-Ophiopogonin D kanye nama-EETs athuthukisa izimpendulo zokuvuvukala ezenziwe i-Ang II ngokuvula i-PPARα kuma-HUVEC.I-Biochem Biophys Res Commun.2017 Aug 19;490(2):123-133.
Isibizo sesiNgisi se-Ophiopogon saponin D
(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranoside β-D-Galactopyranoside, (1β,3β,25R)-3-hydroxyspirost-5-en-1-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[β-D-xylopyranosyl-(1->3)]-6-deoxy-
(2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-5-hydroxy-2-(((4R,5'R,6R,6aR,6bS,8aS) ,8bR,9S,10R,11aS,12aS,12bS)-4-hydroxy-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a, 6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2 '-pyran]-6-yl)oxy)-6-methyl-4-(((2S,3R,4S,5R) -3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro- 2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol
Ophiopogonin D
I-Deacetylophiopogonin C
